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Alastair Smith
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Journal Articles

A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment

Available to Purchase
Grace A Meaker, Matthew Nicholls, Catherine Chahrour, Ian Hsu, Alastair Smith, Yavor Bozhilov, Maurice Ga Hay Leung, Hugo Vassort, Mr, Leonid Olender, Oliver Beaven, Xinran Huang, Elizabeth J Brown, Marlies Vanden Bempt, Hwei Minn Khoo, Joydeep Bhadury, Thomas A Milne, Adam C. Wilkinson
Journal: Blood
Blood blood.2025029115.
https://doi.org/10.1182/blood.2025029115
Published: 2025
Includes: Supplemental data
Journal Articles

Establishment and Characterization of a Model of Acquired Resistance to DOT1L Inhibition in KMT2A -Rearranged Acute Lymphoblastic Leukemia Cells

Free
Pauline Schneider, Susan T.C.J.M. Arentsen-Peters, Nicholas T. Crump, Alastair Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Kirsten S. Vrenken, Dedeke rockx-Brouwer, Ziqin Tang, Wilbert P. Vermeij, Anja De Jong, Bianca Koopmans, M.Emmy M. Dolman, Thomas A. Milne, Rob Pieters, Ronald W. Stam
Journal: Blood
Blood (2022) 140 (Supplement 1): 8760–8761.
https://doi.org/10.1182/blood-2022-166310
Published: 2022
Journal Articles

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

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Douglas RA RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Sarah Mackie, Roan Hulks, Olena Yavorska, Paulina Siejka-Zielinska, Marlen Metzner, Alastair Smith, Batchimeg Usukhbayar, Virginie Penard-Lacronique, Chunxiao Song, Anita K. Gandhi, Maroof Hasan, Paresh Vyas, Thomas A. Milne, Skirmantas Kriaucionis, Lynn Quek
Journal: Blood
Blood (2022) 140 (Supplement 1): 8698–8699.
https://doi.org/10.1182/blood-2022-165898
Published: 2022
Journal Articles

Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression

Free
Douglas RA Silveira, Prodromos Chatzikyriakou, Olena Yavorska, Sarah Mackie, Roan Hulks, Paulina Siejka-Zielinska, Anna Corby, Alastair Smith, Benjamin Brown, Marlen Metzner, Thomas A. Milne, Virginie Penard-Lacronique, Chunxiao Song, Maroof Hasan, Anjan Thakurta, Paresh Vyas, Skirmantas Kriaucionis, Lynn Quek
Journal: Blood
Blood (2021) 138 (Supplement 1): 3467.
https://doi.org/10.1182/blood-2021-149519
Published: 2021
Journal Articles

V H Gene Analysis of IgM-Secreting Myeloma Indicates an Origin From a Memory Cell Undergoing Isotype Switch Events

Free
Surinder S. Sahota, Richard Garand, Razeen Mahroof, Alastair Smith, Nadine Juge-Morineau, Freda K. Stevenson, Regis Bataille
Journal: Blood
Blood (1999) 94 (3): 1070–1076.
https://doi.org/10.1182/blood.V94.3.1070.415k25_1070_1076
Published: 1999