Table 4.

Multivariable analysis according to the Fine and Gray model of variables affecting main outcomes

NRMDisease relapseOverall survivalPFSGRFS
MultivariableMultivariableMultivariableMultivariableMultivariable
VariableHR95% CIPHR95% CIPHR95% CIPHR95% CIPHR95% CIP
Donor age, per 5-y increase 1.05 1.00, 1.10 .057 0.92 0.88, 0.97 .001 0.98 0.94, 1.01 .230 0.97 0.94, 1.00 .036 1.00 0.98, 1.02 .974 
Recipient age, per 5-y increase 1.10 1.03, 1.17 .004 0.98 0.93, 1.04 .518 1.03 1.01, 1.05 .001 1.03 1.00, 1.06 .067 1.04 1.00, 1.09 .066 
Recipient sex: female vs male 1.14 0.82, 1.57 .431 1.08 0.90, 1.31 .402 1.03 0.75, 1.42 .842 1.14 0.86, 1.52 .358 1.17 0.96, 1.41 .116 
Disease type: myeloid vs lymphoid 1.16 0.81, 1.68 .422 0.76 0.53, 1.11 .153 1.00 0.66, 1.53 .983 0.85 0.60, 1.21 .368 0.83 0.63, 1.09 .171 
PR vs CR status before haplo-SCT 1.31 0.92, 1.87 .137 0.99 0.54, 1.81 .967 1.03 0.69, 1.53 .891 1.12 0.81, 1.55 .503 1.12 0.89, 1.42 .330 
PD vs CR status before haplo-SCT 1.61 1.29, 2.01 <.001 2.50 1.95, 3.21 <.001 2.57 1.99, 3.31 <.001 2.62 2.12, 3.25 <.001 2.54 2.20, 2.93 <.001 
Sex D/R: F→M vs not F→M 1.32 0.81, 2.15 .259 0.96 0.54, 1.69 .889 1.07 0.82, 1.41 .608 1.13 0.87, 1.47 .363 1.29 1.05, 1.60 .017 
CMV recipient positive vs negative 1.74 1.02, 2.99 .042 1.13 0.92, 1.40 .247 1.46 1.23, 1.72 <.001 1.50 1.23, 1.83 <.001 1.58 1.42, 1.76 <.001 
HCT-CI ≥3 vs <3 1.30 0.90, 1.89 .166 1.18 0.85, 1.64 .332 1.34 1.12, 1.60 .002 1.32 1.2, 1.45 <.001 1.53 1.43, 1.65 <.001 
Source: PBSC vs BM 1.22 0.71, 2.09 .472 .86 0.70, 1.05 .135 1.00 0.72, 1.38 1.000 1.05 0.79, 1.40 .731 1.11 0.88, 1.39 .391 
Conditioning: MAC vs RIC/NMA 1.08 0.79, 1.47 .626 1.04 0.87, 1.23 .695 0.95 0.78, 1.15 .597 1.03 0.87, 1.22 .733 1.12 0.98, 1.29 .095 
NRMDisease relapseOverall survivalPFSGRFS
MultivariableMultivariableMultivariableMultivariableMultivariable
VariableHR95% CIPHR95% CIPHR95% CIPHR95% CIPHR95% CIP
Donor age, per 5-y increase 1.05 1.00, 1.10 .057 0.92 0.88, 0.97 .001 0.98 0.94, 1.01 .230 0.97 0.94, 1.00 .036 1.00 0.98, 1.02 .974 
Recipient age, per 5-y increase 1.10 1.03, 1.17 .004 0.98 0.93, 1.04 .518 1.03 1.01, 1.05 .001 1.03 1.00, 1.06 .067 1.04 1.00, 1.09 .066 
Recipient sex: female vs male 1.14 0.82, 1.57 .431 1.08 0.90, 1.31 .402 1.03 0.75, 1.42 .842 1.14 0.86, 1.52 .358 1.17 0.96, 1.41 .116 
Disease type: myeloid vs lymphoid 1.16 0.81, 1.68 .422 0.76 0.53, 1.11 .153 1.00 0.66, 1.53 .983 0.85 0.60, 1.21 .368 0.83 0.63, 1.09 .171 
PR vs CR status before haplo-SCT 1.31 0.92, 1.87 .137 0.99 0.54, 1.81 .967 1.03 0.69, 1.53 .891 1.12 0.81, 1.55 .503 1.12 0.89, 1.42 .330 
PD vs CR status before haplo-SCT 1.61 1.29, 2.01 <.001 2.50 1.95, 3.21 <.001 2.57 1.99, 3.31 <.001 2.62 2.12, 3.25 <.001 2.54 2.20, 2.93 <.001 
Sex D/R: F→M vs not F→M 1.32 0.81, 2.15 .259 0.96 0.54, 1.69 .889 1.07 0.82, 1.41 .608 1.13 0.87, 1.47 .363 1.29 1.05, 1.60 .017 
CMV recipient positive vs negative 1.74 1.02, 2.99 .042 1.13 0.92, 1.40 .247 1.46 1.23, 1.72 <.001 1.50 1.23, 1.83 <.001 1.58 1.42, 1.76 <.001 
HCT-CI ≥3 vs <3 1.30 0.90, 1.89 .166 1.18 0.85, 1.64 .332 1.34 1.12, 1.60 .002 1.32 1.2, 1.45 <.001 1.53 1.43, 1.65 <.001 
Source: PBSC vs BM 1.22 0.71, 2.09 .472 .86 0.70, 1.05 .135 1.00 0.72, 1.38 1.000 1.05 0.79, 1.40 .731 1.11 0.88, 1.39 .391 
Conditioning: MAC vs RIC/NMA 1.08 0.79, 1.47 .626 1.04 0.87, 1.23 .695 0.95 0.78, 1.15 .597 1.03 0.87, 1.22 .733 1.12 0.98, 1.29 .095 
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