Effect of parent vs sibling donor in recipients 40 y or younger
| . | Parent vs sibling . | Father vs sibling . | Mother vs sibling . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Grade 2-4 aGVHD | .97 | .48,1.96 | .933 | 1.42 | .61,3.31 | .421 | .74 | .41,1.33 | .309 |
| Grade 3-4 aGVHD | 1.35 | .45,4.04 | .594 | 2.22 | .34,14.74 | .407 | .97 | .27,3.49 | .968 |
| Moderate-severe cGVHD | 1.96 | .8,4.78 | .139 | 2.46 | 1.18,5.16 | .017 | 1.72 | .67,4.41 | .257 |
| NRM | 1.2 | .87,1.66 | .263 | 1.59 | .91,2.78 | .102 | .97 | .54,1.75 | .924 |
| Cumulative incidence of relapse | 1.39 | 1.19,1.63 | <.001 | 1.13 | .75,1.71 | .55 | 1.64 | 1.24,2.18 | .001 |
| Overall survival | 1.19 | .92,1.53 | .176 | 1.09 | .9,1.33 | .373 | 1.23 | .88,1.72 | .218 |
| PFS | 1.32 | 1.15,1.52 | <.001 | 1.24 | 1.06,1.46 | .008 | 1.42 | 1.07,1.88 | .015 |
| GRFS | 1.54 | 1.38,1.72 | <.001 | 1.57 | 1.4,1.77 | <.001 | 1.71 | 1.3,2.26 | <.001 |
| . | Parent vs sibling . | Father vs sibling . | Mother vs sibling . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | P . |
| Grade 2-4 aGVHD | .97 | .48,1.96 | .933 | 1.42 | .61,3.31 | .421 | .74 | .41,1.33 | .309 |
| Grade 3-4 aGVHD | 1.35 | .45,4.04 | .594 | 2.22 | .34,14.74 | .407 | .97 | .27,3.49 | .968 |
| Moderate-severe cGVHD | 1.96 | .8,4.78 | .139 | 2.46 | 1.18,5.16 | .017 | 1.72 | .67,4.41 | .257 |
| NRM | 1.2 | .87,1.66 | .263 | 1.59 | .91,2.78 | .102 | .97 | .54,1.75 | .924 |
| Cumulative incidence of relapse | 1.39 | 1.19,1.63 | <.001 | 1.13 | .75,1.71 | .55 | 1.64 | 1.24,2.18 | .001 |
| Overall survival | 1.19 | .92,1.53 | .176 | 1.09 | .9,1.33 | .373 | 1.23 | .88,1.72 | .218 |
| PFS | 1.32 | 1.15,1.52 | <.001 | 1.24 | 1.06,1.46 | .008 | 1.42 | 1.07,1.88 | .015 |
| GRFS | 1.54 | 1.38,1.72 | <.001 | 1.57 | 1.4,1.77 | <.001 | 1.71 | 1.3,2.26 | <.001 |