Main clinical and electrophysiologic characteristics of CANOMAD/CANDA patients
| Characteristics . | No. (%) or median (range) . |
|---|---|
| Total | 45 (100) |
| Male | 35 (78) |
| Age at CANOMAD/CANDA diagnosis, y | |
| Median (range) | 62 (38-81) |
| Time from onset of symptoms to CANOMAD/CANDA diagnosis, y | |
| Median (range) | 4 (0.1-27) |
| Type of onset | |
| Acute | 8 (18) |
| Subacute (rapidly progressive) | 7 (15) |
| Chronic (slowly progressive) | 30 (67) |
| Neurologic symptoms at diagnosis | |
| Sensory symptoms | 35 (78) |
| Paresthesia | 26 (58) |
| Ataxia | 21 (47) |
| Ophthalmoplegia | 6 (13) |
| Bulbar symptoms | 3 (7) |
| Others | 14 (30) |
| Painful limb | 6 (13) |
| Motor weakness/myoclonus | 3 (7) |
| Acrocyanosis/livedo | 2 (4) |
| Dyspnea | 1 (2) |
| Facial nerve paralysis | 2 (4) |
| Neurologic symptoms during the course of the disease | |
| Sensory ataxia | 34 (76) |
| Paresthesia | 35 (78) |
| Hypoesthesia | 42 (93) |
| Upper and lower limbs | 24 (53) |
| Lower limbs only | 18 (40) |
| Ophthalmoplegia | 20 (44) |
| Bulbar symptoms | 6 (13) |
| Motor weakness | 18 (40) |
| Upper and lower limbs | 13 (29) |
| Lower limbs only | 5 (11) |
| Areflexia | 42 (93) |
| Facial nerve paralysis | 3 (7) |
| Dysautonomic signs | 2 (4) |
| Acute respiratory distress | 3 (7) |
| Modified Rankin score at diagnosis | /42 |
| 0 (asymptomatic) | 0 (0) |
| 1 (symptomatic but no significant disability) | 15 (36) |
| 2 (slight disability) | 8 (19) |
| 3 (moderate disability) | 7 (17) |
| 4 (moderately severe disability) | 10 (24) |
| 5 (severe disability) | 2 (5) |
| Electrophysiologic findings, pattern | |
| Demyelinating | 27 (60) |
| Axonal | 12 (27) |
| Normal | 6 (3) |
| Type of evolution | |
| Relapsing-remitting | 14 (31) |
| Chronic progressive | 30 (67) |
| Isolated symptomatic flare-up | 1 (2) |
| Characteristics . | No. (%) or median (range) . |
|---|---|
| Total | 45 (100) |
| Male | 35 (78) |
| Age at CANOMAD/CANDA diagnosis, y | |
| Median (range) | 62 (38-81) |
| Time from onset of symptoms to CANOMAD/CANDA diagnosis, y | |
| Median (range) | 4 (0.1-27) |
| Type of onset | |
| Acute | 8 (18) |
| Subacute (rapidly progressive) | 7 (15) |
| Chronic (slowly progressive) | 30 (67) |
| Neurologic symptoms at diagnosis | |
| Sensory symptoms | 35 (78) |
| Paresthesia | 26 (58) |
| Ataxia | 21 (47) |
| Ophthalmoplegia | 6 (13) |
| Bulbar symptoms | 3 (7) |
| Others | 14 (30) |
| Painful limb | 6 (13) |
| Motor weakness/myoclonus | 3 (7) |
| Acrocyanosis/livedo | 2 (4) |
| Dyspnea | 1 (2) |
| Facial nerve paralysis | 2 (4) |
| Neurologic symptoms during the course of the disease | |
| Sensory ataxia | 34 (76) |
| Paresthesia | 35 (78) |
| Hypoesthesia | 42 (93) |
| Upper and lower limbs | 24 (53) |
| Lower limbs only | 18 (40) |
| Ophthalmoplegia | 20 (44) |
| Bulbar symptoms | 6 (13) |
| Motor weakness | 18 (40) |
| Upper and lower limbs | 13 (29) |
| Lower limbs only | 5 (11) |
| Areflexia | 42 (93) |
| Facial nerve paralysis | 3 (7) |
| Dysautonomic signs | 2 (4) |
| Acute respiratory distress | 3 (7) |
| Modified Rankin score at diagnosis | /42 |
| 0 (asymptomatic) | 0 (0) |
| 1 (symptomatic but no significant disability) | 15 (36) |
| 2 (slight disability) | 8 (19) |
| 3 (moderate disability) | 7 (17) |
| 4 (moderately severe disability) | 10 (24) |
| 5 (severe disability) | 2 (5) |
| Electrophysiologic findings, pattern | |
| Demyelinating | 27 (60) |
| Axonal | 12 (27) |
| Normal | 6 (3) |
| Type of evolution | |
| Relapsing-remitting | 14 (31) |
| Chronic progressive | 30 (67) |
| Isolated symptomatic flare-up | 1 (2) |