Baseline characteristics of patients recruited to Myeloma XI by treatment pathway
| Characteristics . | Total . | Intensive pathway . | Nonintensive pathway . | P . |
|---|---|---|---|---|
| N or n (%) | 4158 | 2435 (58.5) | 1723 (41.4) | |
| Age, y | ||||
| Median (IQR) | 71 (78-64) | 65 (70-59) | 79 (83-75) | <.001 |
| Sex, n (%) | ||||
| Male:female | 2439 (59):1719 (41) | 1462 (60):973 (40) | 977 (57):746 (43) | .031 |
| Ethnicity, n (%) | ||||
| White: others | 3880 (93):278 (7) | 2255 (93):180 (7) | 1625 (94):98 (6) | .199 |
| Myeloma type, n (%) | ||||
| IgG | 2252 (54) | 1296 (53) | 956 (55.5) | .001 |
| IgA | 919 (22) | 519 (21) | 400 (23.2) | |
| LCO | 491 (12) | 325 (13) | 166 (9.6) | |
| No paraprotein | 32 (0.8) | 20 (0.8) | 12 (0.7) | |
| IgD | 42 (1) | 33 (1.4) | 9 (0.5) | |
| IgM | 8 (0.2) | 6 (0.2) | 2 (0.1) | |
| Missing | 414 (10) | 236 (9.7) | 178 (10.4) | |
| FLC isotype, n (%) | ||||
| κ | 2449 (59) | 1421 (58.4) | 1028 (60) | .177 |
| λ | 1260 (30) | 757 (31) | 503 (29) | |
| Missing | 449 (11) | 257 (10) | 192 (11) | |
| dFLC κ, mg/L | ||||
| Median (IQR) | 320 (44-984) | 292 (40-901) | 370 (72.5-1124) | .008 |
| dFLC λ, mg/L | ||||
| Median (IQR) | 406 (69-1127) | 429 (69-1143) | 380 (63-1098) | .575 |
| Baseline eGFR, mLper min per 1.73 m2 | ||||
| Median (IQR) | 64 (49-81) | 68 (54-85) | 58 (44-75) | <.001 |
| Baseline eGFR, n (%), mL per min per 1.7 3 m2 | ||||
| eGFR >59 | 2271 (55) | 1514 (62) | 757 (44) | <.001 |
| eGFR 30-59 | 1366 (33) | 658 (27) | 708 (41) | |
| eGFR <30 | 256 (6.2) | 122 (5) | 134 (7.7) | |
| Missing | 265 (6.4) | 141 (6) | 124 (7) | |
| Baseline dFLC, n (%), mg/L | ||||
| <500 | 2314 (56) | 1379 (57) | 935 (54) | <.001 |
| 500-1000 | 596 (14) | 356 (15) | 240 (14) | |
| ≥1001 | 995 (24) | 559 (23) | 436 (25) | |
| Missing | 253 (6) | 141 (6) | 112 (6.5) | |
| dFLC response, n (%) | ||||
| <50% | 125 (3) | 34 (1.4) | 91 (5.2) | <.001 |
| 50%-90% | 290 (7) | 86 (3.5) | 204 (12) | |
| >90% | 1239 (30) | 879 (36.1) | 360 (21) | |
| Baseline dFLC <100 | 1160 (28) | 718 (29.4) | 442 (25.6) | |
| Missing | 1344 (32) | 718 (29.4) | 626 (36.3) |
| Characteristics . | Total . | Intensive pathway . | Nonintensive pathway . | P . |
|---|---|---|---|---|
| N or n (%) | 4158 | 2435 (58.5) | 1723 (41.4) | |
| Age, y | ||||
| Median (IQR) | 71 (78-64) | 65 (70-59) | 79 (83-75) | <.001 |
| Sex, n (%) | ||||
| Male:female | 2439 (59):1719 (41) | 1462 (60):973 (40) | 977 (57):746 (43) | .031 |
| Ethnicity, n (%) | ||||
| White: others | 3880 (93):278 (7) | 2255 (93):180 (7) | 1625 (94):98 (6) | .199 |
| Myeloma type, n (%) | ||||
| IgG | 2252 (54) | 1296 (53) | 956 (55.5) | .001 |
| IgA | 919 (22) | 519 (21) | 400 (23.2) | |
| LCO | 491 (12) | 325 (13) | 166 (9.6) | |
| No paraprotein | 32 (0.8) | 20 (0.8) | 12 (0.7) | |
| IgD | 42 (1) | 33 (1.4) | 9 (0.5) | |
| IgM | 8 (0.2) | 6 (0.2) | 2 (0.1) | |
| Missing | 414 (10) | 236 (9.7) | 178 (10.4) | |
| FLC isotype, n (%) | ||||
| κ | 2449 (59) | 1421 (58.4) | 1028 (60) | .177 |
| λ | 1260 (30) | 757 (31) | 503 (29) | |
| Missing | 449 (11) | 257 (10) | 192 (11) | |
| dFLC κ, mg/L | ||||
| Median (IQR) | 320 (44-984) | 292 (40-901) | 370 (72.5-1124) | .008 |
| dFLC λ, mg/L | ||||
| Median (IQR) | 406 (69-1127) | 429 (69-1143) | 380 (63-1098) | .575 |
| Baseline eGFR, mLper min per 1.73 m2 | ||||
| Median (IQR) | 64 (49-81) | 68 (54-85) | 58 (44-75) | <.001 |
| Baseline eGFR, n (%), mL per min per 1.7 3 m2 | ||||
| eGFR >59 | 2271 (55) | 1514 (62) | 757 (44) | <.001 |
| eGFR 30-59 | 1366 (33) | 658 (27) | 708 (41) | |
| eGFR <30 | 256 (6.2) | 122 (5) | 134 (7.7) | |
| Missing | 265 (6.4) | 141 (6) | 124 (7) | |
| Baseline dFLC, n (%), mg/L | ||||
| <500 | 2314 (56) | 1379 (57) | 935 (54) | <.001 |
| 500-1000 | 596 (14) | 356 (15) | 240 (14) | |
| ≥1001 | 995 (24) | 559 (23) | 436 (25) | |
| Missing | 253 (6) | 141 (6) | 112 (6.5) | |
| dFLC response, n (%) | ||||
| <50% | 125 (3) | 34 (1.4) | 91 (5.2) | <.001 |
| 50%-90% | 290 (7) | 86 (3.5) | 204 (12) | |
| >90% | 1239 (30) | 879 (36.1) | 360 (21) | |
| Baseline dFLC <100 | 1160 (28) | 718 (29.4) | 442 (25.6) | |
| Missing | 1344 (32) | 718 (29.4) | 626 (36.3) |
Boldface P values signify statistical significance (P < .05).
Ig, immunoglobulin; LCO, light chain only.