Univariate and multivariate analysis of factors associated with improvement and decline in renal function at 12 mo
| Variables . | Univariate analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| Improvement | ||||||
| Age, y | .007 | <.001 | ||||
| <70 | 1.31 (1.07-1.60) | 1.58 (1.23-2.04) | ||||
| ≥70 | Reference | Reference | ||||
| Sex | .009 | <.001 | ||||
| Male | 1.37 (1.08-1.75) | 1.62 (1.26-2.09) | ||||
| Female | Reference | Reference | ||||
| Baseline dFLC, mg/L | ||||||
| >1000 | 1.98 (1.53-2.57) | <.001 | 1.69 (1.28-2.22) | <.001 | ||
| 500-1000 | 1.06 (0.77-1.46) | <.001 | 0.98 (0.70-1.36) | <.001 | ||
| <500 | Reference | .70 | Reference | .91 | ||
| Average eGFR, mL/min | ||||||
| <30 | 2.90 (1.82-4.64) | <.001 | 3.35 (1.96-5.73) | <.001 | ||
| 30-59 | 1.69 (1.37-2.08) | <.001 | 2.23 (1.73-2.87) | <.001 | ||
| ≥60 | Reference | <.001 | Reference | <.001 | ||
| dFLC response, % | ||||||
| >90 | 2.01 (1.18-3.42) | .012 | 1.92 (1.11-3.34) | .04 | ||
| 50-90 | 1.53 (0.84-2.75) | .010 | 1.55 (0.84-2.84) | .02 | ||
| <50 | Reference | .15 | Reference | .15 | ||
| Decline | ||||||
| Age, y | .001 | .05 | ||||
| <70 | 0.70 (0.54-0.84) | 0.74 (0.55-1.00) | ||||
| ≥70 | Reference | Reference | ||||
| Sex | .002 | .01 | ||||
| Female | 1.41 (1.12-1.75) | 1.42 (1.08-1.88) | ||||
| Male | Reference | Reference | ||||
| Baseline dFLC, mg/L | .14 | |||||
| <500 | 1.37 (0.99-1.88) | .05 | 1.33 (0.95-1.86) | .22 | ||
| 500-1000 | 1.18 (0.80-1.73) | .39 | 1.23 (0.82-1.83) | .08 | ||
| >1000 | Reference | Reference | .30 | |||
| Average eGFR, mL/min | ||||||
| <30 | 1.17 (0.65-2.13) | .15 | 1.12 (0.55-2.26) | .78 | ||
| 30-59 | 1.25 (0.99-1.58) | .59 | 1.10 (0.82-1.49) | .74 | ||
| ≥60 | Reference | .05 | Reference | .50 | ||
| dFLC response, % | ||||||
| >90 | 0.34 (0.22-0.52) | <.001 | 0.39 (0.20-0.60) | <.001 | ||
| 50-90 | 0.32 (0.19-0.55) | <.001 | 0.34 (0.20-0.57) | <.001 | ||
| <50 | Reference | <.001 | Reference | <.001 | ||
| Variables . | Univariate analysis . | Multivariable analysis . | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| Improvement | ||||||
| Age, y | .007 | <.001 | ||||
| <70 | 1.31 (1.07-1.60) | 1.58 (1.23-2.04) | ||||
| ≥70 | Reference | Reference | ||||
| Sex | .009 | <.001 | ||||
| Male | 1.37 (1.08-1.75) | 1.62 (1.26-2.09) | ||||
| Female | Reference | Reference | ||||
| Baseline dFLC, mg/L | ||||||
| >1000 | 1.98 (1.53-2.57) | <.001 | 1.69 (1.28-2.22) | <.001 | ||
| 500-1000 | 1.06 (0.77-1.46) | <.001 | 0.98 (0.70-1.36) | <.001 | ||
| <500 | Reference | .70 | Reference | .91 | ||
| Average eGFR, mL/min | ||||||
| <30 | 2.90 (1.82-4.64) | <.001 | 3.35 (1.96-5.73) | <.001 | ||
| 30-59 | 1.69 (1.37-2.08) | <.001 | 2.23 (1.73-2.87) | <.001 | ||
| ≥60 | Reference | <.001 | Reference | <.001 | ||
| dFLC response, % | ||||||
| >90 | 2.01 (1.18-3.42) | .012 | 1.92 (1.11-3.34) | .04 | ||
| 50-90 | 1.53 (0.84-2.75) | .010 | 1.55 (0.84-2.84) | .02 | ||
| <50 | Reference | .15 | Reference | .15 | ||
| Decline | ||||||
| Age, y | .001 | .05 | ||||
| <70 | 0.70 (0.54-0.84) | 0.74 (0.55-1.00) | ||||
| ≥70 | Reference | Reference | ||||
| Sex | .002 | .01 | ||||
| Female | 1.41 (1.12-1.75) | 1.42 (1.08-1.88) | ||||
| Male | Reference | Reference | ||||
| Baseline dFLC, mg/L | .14 | |||||
| <500 | 1.37 (0.99-1.88) | .05 | 1.33 (0.95-1.86) | .22 | ||
| 500-1000 | 1.18 (0.80-1.73) | .39 | 1.23 (0.82-1.83) | .08 | ||
| >1000 | Reference | Reference | .30 | |||
| Average eGFR, mL/min | ||||||
| <30 | 1.17 (0.65-2.13) | .15 | 1.12 (0.55-2.26) | .78 | ||
| 30-59 | 1.25 (0.99-1.58) | .59 | 1.10 (0.82-1.49) | .74 | ||
| ≥60 | Reference | .05 | Reference | .50 | ||
| dFLC response, % | ||||||
| >90 | 0.34 (0.22-0.52) | <.001 | 0.39 (0.20-0.60) | <.001 | ||
| 50-90 | 0.32 (0.19-0.55) | <.001 | 0.34 (0.20-0.57) | <.001 | ||
| <50 | Reference | <.001 | Reference | <.001 | ||
All ORs have been quoted relative to the reference categories. Boldface P values signify statistical significance (P < .05).