Long-term survival estimates in the intent-to-treat population
| End point . | Treatment-naive patients in need of therapy . | Randomized patients . | ||||||
|---|---|---|---|---|---|---|---|---|
| All (N = 97) . | Short maintenance (n = 46) . | Long maintenance (n = 51) . | P* . | All (N = 165) . | Short maintenance (n = 82) . | Long maintenance (n = 83) . | P* . | |
| EFS | ||||||||
| Median (95% CI), y | 5.1 (3.1-7.4) | 5.5 (2.1-9.8) | 5.0 (2.6-NA) | .924 | 4.3 (3.1-5.6) | 3.4 (2.1-5.5) | 5.3 (3.5-7.5) | .385 |
| 10-y (95% CI), % | 36.3 (26.2-46.5) | 34.2 (19.1-49.9) | 38.8 (25.5-51.9) | .608 | 31.5 (24.1-39.1) | 27.8 (17.6-39.0) | 34.9 (24.6-45.3) | .364 |
| PFS | ||||||||
| Median (95% CI), y | 7.4 (4.6-NA) | 6.6 (2.1-NA) | 7.4 (4.0-NA) | .739 | 5.9 (3.6-7.6) | 3.5 (2.1-6.6) | 7.4 (5.5-9.5) | .189 |
| 10-y (95% CI), % | 42.5.0 (31.4-53.3) | 43.9 (27.2-59.3) | 42.0 (27.2-56.1) | .869 | 36.0 (27.9-44.1) | 34.8 (23.5-46.3) | 37.8 (26.6-48.9) | .716 |
| OS | ||||||||
| Median (95% CI), y | 11.0 (NA) | 11.0 (NA) | Not reached (NA) | .521 | 11.0 (11.0-NA) | 11.0 (11.0-NA) | Not reached (NA) | .797 |
| 10-y (95% CI), % | 83.2 (73.6-89.5) | 80.7 (65.0-89.9) | 85.3 (71.6-92.7) | .567 | 78.4 (70.7-84.3) | 77.9 (66.3-85.9) | 79.0 (67.9-86.7) | .867 |
| End point . | Treatment-naive patients in need of therapy . | Randomized patients . | ||||||
|---|---|---|---|---|---|---|---|---|
| All (N = 97) . | Short maintenance (n = 46) . | Long maintenance (n = 51) . | P* . | All (N = 165) . | Short maintenance (n = 82) . | Long maintenance (n = 83) . | P* . | |
| EFS | ||||||||
| Median (95% CI), y | 5.1 (3.1-7.4) | 5.5 (2.1-9.8) | 5.0 (2.6-NA) | .924 | 4.3 (3.1-5.6) | 3.4 (2.1-5.5) | 5.3 (3.5-7.5) | .385 |
| 10-y (95% CI), % | 36.3 (26.2-46.5) | 34.2 (19.1-49.9) | 38.8 (25.5-51.9) | .608 | 31.5 (24.1-39.1) | 27.8 (17.6-39.0) | 34.9 (24.6-45.3) | .364 |
| PFS | ||||||||
| Median (95% CI), y | 7.4 (4.6-NA) | 6.6 (2.1-NA) | 7.4 (4.0-NA) | .739 | 5.9 (3.6-7.6) | 3.5 (2.1-6.6) | 7.4 (5.5-9.5) | .189 |
| 10-y (95% CI), % | 42.5.0 (31.4-53.3) | 43.9 (27.2-59.3) | 42.0 (27.2-56.1) | .869 | 36.0 (27.9-44.1) | 34.8 (23.5-46.3) | 37.8 (26.6-48.9) | .716 |
| OS | ||||||||
| Median (95% CI), y | 11.0 (NA) | 11.0 (NA) | Not reached (NA) | .521 | 11.0 (11.0-NA) | 11.0 (11.0-NA) | Not reached (NA) | .797 |
| 10-y (95% CI), % | 83.2 (73.6-89.5) | 80.7 (65.0-89.9) | 85.3 (71.6-92.7) | .567 | 78.4 (70.7-84.3) | 77.9 (66.3-85.9) | 79.0 (67.9-86.7) | .867 |
NA, not assessable.
Log-rank test and 2-sample test for survival curves at a fixed point in time (see "Patients and methods").