Table 2.

Definitions of terms used to capture heavy or otherwise abnormal menstrual bleeding in the literature

TermDefinition
Heavy menstrual bleeding (HMB)/menorrhagia Menstrual blood loss (MBL) of >80 mL/cycle or Pictorial Blood Loss Assessment Chart score >100 
Abnormal uterine bleeding (AUB) Menstrual bleeding of abnormal quantity, duration, or schedule. Includes heavy bleeding; excessively frequent, infrequent, or irregular bleeding; and intermenstrual bleeding. 
Clinically relevant non-major bleeding (CRMNB) Uterine bleeding that requires medical intervention by a health care professional, leads to hospitalization or increased level of care, or prompts a face-to-face evaluation 
Major bleeding (MB) Uterine bleeding that is fatal or causes a fall in hemoglobin level of ≥20 g/L (≥2 g/dL) or leading to transfusion of ≥2 units of whole blood or red cells 
TermDefinition
Heavy menstrual bleeding (HMB)/menorrhagia Menstrual blood loss (MBL) of >80 mL/cycle or Pictorial Blood Loss Assessment Chart score >100 
Abnormal uterine bleeding (AUB) Menstrual bleeding of abnormal quantity, duration, or schedule. Includes heavy bleeding; excessively frequent, infrequent, or irregular bleeding; and intermenstrual bleeding. 
Clinically relevant non-major bleeding (CRMNB) Uterine bleeding that requires medical intervention by a health care professional, leads to hospitalization or increased level of care, or prompts a face-to-face evaluation 
Major bleeding (MB) Uterine bleeding that is fatal or causes a fall in hemoglobin level of ≥20 g/L (≥2 g/dL) or leading to transfusion of ≥2 units of whole blood or red cells 
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