Summary of genome-wide association studies used in the summary statistics–based 2-sample mendelian randomization analyses
| Phenotype . | Sample size . | Consortium/study . |
|---|---|---|
| Exposures | ||
| Fibrinogen levels | 120 246 | CHARGE Hemostasis21 |
| γ′ fibrinogen levels | 9225 | ARIC study |
| Main outcomes | ||
| Venous thromboembolism | 7507 cases/52 632 controls | INVENT consortium9 |
| Any ischemic stroke | 34 217 cases/406 111 controls | MEGASTROKE10 |
| Cardioembolic stroke | 7193 cases/322 150 controls | MEGASTROKE10 |
| Large artery stroke | 4373 cases/204 991 controls | MEGASTROKE10 |
| Small vessel disease | 5386 cases/254 558 controls | MEGASTROKE10 |
| Additional phenotypes | ||
| C-reactive protein levels | 148 164 | CHARGE Inflammation22 |
| D-dimer levels | 21 052 | CHARGE Hemostasis23 |
| Phenotype . | Sample size . | Consortium/study . |
|---|---|---|
| Exposures | ||
| Fibrinogen levels | 120 246 | CHARGE Hemostasis21 |
| γ′ fibrinogen levels | 9225 | ARIC study |
| Main outcomes | ||
| Venous thromboembolism | 7507 cases/52 632 controls | INVENT consortium9 |
| Any ischemic stroke | 34 217 cases/406 111 controls | MEGASTROKE10 |
| Cardioembolic stroke | 7193 cases/322 150 controls | MEGASTROKE10 |
| Large artery stroke | 4373 cases/204 991 controls | MEGASTROKE10 |
| Small vessel disease | 5386 cases/254 558 controls | MEGASTROKE10 |
| Additional phenotypes | ||
| C-reactive protein levels | 148 164 | CHARGE Inflammation22 |
| D-dimer levels | 21 052 | CHARGE Hemostasis23 |