Estimated COVID-19 outcome predictors based on multivariate analysis and their ORs for MM patients
| Variable . | P . | OR (95% CI) . |
|---|---|---|
| Age | .006 | 1.04 (1.01-1.08) |
| ISS3 | .899 | 1.05 (0.49-2.22) |
| High-risk disease | .013 | 2.35 (1.20-4.66) |
| Renal disease | .014 | 2.71 (1.23-6.08) |
| Active disease or PD | .063 | 1.91 (0.96-3.81) |
| Comorbidities | .711 | 0.88 (0.44-1.75) |
| Prior anti-CD38 | .558 | 0.77 (0.31-1.85) |
| Active anti-CD38 | .262 | 1.68 (0.68-4.21) |
| Active IMiD | .769 | 1.10 (0.59-2.07) |
| Variable . | P . | OR (95% CI) . |
|---|---|---|
| Age | .006 | 1.04 (1.01-1.08) |
| ISS3 | .899 | 1.05 (0.49-2.22) |
| High-risk disease | .013 | 2.35 (1.20-4.66) |
| Renal disease | .014 | 2.71 (1.23-6.08) |
| Active disease or PD | .063 | 1.91 (0.96-3.81) |
| Comorbidities | .711 | 0.88 (0.44-1.75) |
| Prior anti-CD38 | .558 | 0.77 (0.31-1.85) |
| Active anti-CD38 | .262 | 1.68 (0.68-4.21) |
| Active IMiD | .769 | 1.10 (0.59-2.07) |
OR for age is calculated by increments of 1 year. High-risk disease includes patients with del 17p, t(4;14), amp 1q or t(14;16) alterations detected by FISH. Renal disease is defined as creatinine clearance <40 mL/min, creatinine >2 mg/dL, or on dialysis. Active disease or PD refers to newly diagnosed or relapsed patients whose MM was not responsive to any treatment or not controlled at the time of COVID-19 diagnosis. Comorbidities refers to 1 or more condition associated with cardiac, neurological, pulmonary, or renal disease, diabetes, and/or hypertension. Prior anti-CD38 refers to anti-CD38 monoclonal antibody usage any time before COVID-19 diagnosis. Active anti-CD38 and active-IMiD refer to using these treatments at the time of COVID-19 diagnosis. Variables with P < .1 were considered statistically significant and are shown in bold.
See Table 2 for expansion of abbreviations.