ICH and anticoagulation management during 12 months of follow-up
| Variable . | Anticoagulation class at index . | |
|---|---|---|
| DOAC . | LMWH . | |
| All patients, n | 41 | 55 |
| Anticoagulation management* | ||
| Anticoagulants stopped | 3 (7.3) | 4 (7.3) |
| Anticoagulant group changed† | 2 (4.9) | 4 (7.3) |
| Spontaneous ICH (any) | 4 (10) | 7 (13) |
| ICH classification | ||
| Major‡ | 2 (4.9) | 6 (10.9) |
| Measurable§ | 2 (4.9) | 0 |
| Trace|| | 0 | 1 (1.8) |
| Radiological characteristics of ICH | ||
| Midline shift | 1 (2.4) | 1 (1.8) |
| Herniation | 0 | 2 (3.6) |
| Volume of largest bleed, median (IQR), mL | 1.4 (0.73-1.8) | 0.7 (0.5-5) |
| Number of distinct bleeds, median (IQR) | 1 (1-2) | 1 (1-2) |
| Fatal ICH | 0 | 3 (5.5) |
| Variable . | Anticoagulation class at index . | |
|---|---|---|
| DOAC . | LMWH . | |
| All patients, n | 41 | 55 |
| Anticoagulation management* | ||
| Anticoagulants stopped | 3 (7.3) | 4 (7.3) |
| Anticoagulant group changed† | 2 (4.9) | 4 (7.3) |
| Spontaneous ICH (any) | 4 (10) | 7 (13) |
| ICH classification | ||
| Major‡ | 2 (4.9) | 6 (10.9) |
| Measurable§ | 2 (4.9) | 0 |
| Trace|| | 0 | 1 (1.8) |
| Radiological characteristics of ICH | ||
| Midline shift | 1 (2.4) | 1 (1.8) |
| Herniation | 0 | 2 (3.6) |
| Volume of largest bleed, median (IQR), mL | 1.4 (0.73-1.8) | 0.7 (0.5-5) |
| Number of distinct bleeds, median (IQR) | 1 (1-2) | 1 (1-2) |
| Fatal ICH | 0 | 3 (5.5) |
Values represent n (%) of patients unless otherwise indicated.
During the 12-month follow-up, before censorship for death or ICH.
Defined as a change from LMWH to DOAC or vice versa.
ICH ≥10 mL in volume, required surgical intervention, or was associated with symptoms. All the patients with major ICH were symptomatic. One LMWH-treated patient also had ICH volume ≥10 mL.
ICH volume ≥1 mL but <10 mL.
ICH volume <1 mL or unmeasurable.