Univariable prognostic factor analyses for OS by ITT (log rank; n = 41/60)
| Variable . | CAR T cells . | alloHCT . | ||||||
|---|---|---|---|---|---|---|---|---|
| P . | HR . | Lower CL . | Upper CL . | P . | HR . | Lower CL . | Upper CL . | |
| Age (<60 vs ≥60 y) | .27 | 1.67 | 0.68 | 4.04 | .12 | 0.56 | 0.27 | 1.17 |
| Male sex | .85 | 0.90 | 0.31 | 2.58 | .18 | 1.56 | 0.82 | 2.95 |
| Diagnosis (DLBCL vs other) | .25 | 0.55 | 0.20 | 1.53 | .016 | 0.47 | 0.25 | 0.87 |
| PIF (vs relapse) | .72 | 0.84 | 0.34 | 2.12 | .039 | 2.11 | 1.04 | 4.27 |
| Time from diagnosis (≤12 vs >12 mo) | .71 | 1.18 | 0.49 | 2.85 | .70 | 1.13 | 0.61 | 2.11 |
| No. of failed lines (CAR, 2 vs >2; HCT, 1 vs >1) | .69 | 1.20 | 0.50 | 2.90 | <.001 | 3.12 | 1.69 | 5.75 |
| AutoHCT failed (yes vs no) | .94 | 0.96 | 0.32 | 2.84 | .81 | 1.08 | 0.59 | 1.97 |
| HCT comorbidity index (>0 vs 0) | .81 | 0.90 | 0.36 | 2.24 | .22 | 0.68 | 0.37 | 1.25 |
| PS (>1 vs 0-1) | .006 | 7.41 | 1.78 | 30.1 | .13 | 2.66 | 0.76 | 9.32 |
| sIPI (HI/H vs L/LI) | .39 | 1.48 | 0.61 | 3.63 | .35 | 1.35 | 0.72 | 2.53 |
| Bulk >10 cm (yes vs no) | .11 | 2.62 | 0.61 | 3.63 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .08 | 2.32 | 0.90 | 5.86 | .015 | 2.19 | 1.17 | 4.12 |
| Need for bridging (yes vs no) | .0011 | 4.92 | 1.89 | 12.9 | — | — | — | — |
| Variable . | CAR T cells . | alloHCT . | ||||||
|---|---|---|---|---|---|---|---|---|
| P . | HR . | Lower CL . | Upper CL . | P . | HR . | Lower CL . | Upper CL . | |
| Age (<60 vs ≥60 y) | .27 | 1.67 | 0.68 | 4.04 | .12 | 0.56 | 0.27 | 1.17 |
| Male sex | .85 | 0.90 | 0.31 | 2.58 | .18 | 1.56 | 0.82 | 2.95 |
| Diagnosis (DLBCL vs other) | .25 | 0.55 | 0.20 | 1.53 | .016 | 0.47 | 0.25 | 0.87 |
| PIF (vs relapse) | .72 | 0.84 | 0.34 | 2.12 | .039 | 2.11 | 1.04 | 4.27 |
| Time from diagnosis (≤12 vs >12 mo) | .71 | 1.18 | 0.49 | 2.85 | .70 | 1.13 | 0.61 | 2.11 |
| No. of failed lines (CAR, 2 vs >2; HCT, 1 vs >1) | .69 | 1.20 | 0.50 | 2.90 | <.001 | 3.12 | 1.69 | 5.75 |
| AutoHCT failed (yes vs no) | .94 | 0.96 | 0.32 | 2.84 | .81 | 1.08 | 0.59 | 1.97 |
| HCT comorbidity index (>0 vs 0) | .81 | 0.90 | 0.36 | 2.24 | .22 | 0.68 | 0.37 | 1.25 |
| PS (>1 vs 0-1) | .006 | 7.41 | 1.78 | 30.1 | .13 | 2.66 | 0.76 | 9.32 |
| sIPI (HI/H vs L/LI) | .39 | 1.48 | 0.61 | 3.63 | .35 | 1.35 | 0.72 | 2.53 |
| Bulk >10 cm (yes vs no) | .11 | 2.62 | 0.61 | 3.63 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .08 | 2.32 | 0.90 | 5.86 | .015 | 2.19 | 1.17 | 4.12 |
| Need for bridging (yes vs no) | .0011 | 4.92 | 1.89 | 12.9 | — | — | — | — |
Bold font indicates significance.
CL, confidence limit of 95% confidence interval; HI/H, high intermediate/high; L/LI, low/low intermediate; PIF, primary induction failure; sIPI, secondary International Prognostic Index.