Univariable prognostic factor analyses for post-CI outcomes (log rank; n=30/39)
| Variable . | CAR T cells . | alloHCT . | ||||||
|---|---|---|---|---|---|---|---|---|
| P . | HR . | Lower CL . | Upper CL . | P . | HR . | Lower CL . | Upper CL . | |
| OS | ||||||||
| Diagnosis (DLBCL vs other) | .59 | 0.66 | 0.15 | 2.97 | .0062 | 0.31 | 0.14 | 0.72 |
| PIF (vs relapse) | .37 | 1.88 | 0.47 | 7.55 | .036 | 2.92 | 1.08 | 7.94 |
| Prior lines (>3 vs 2-3) | .62 | 1.02 | 0.75 | 1.29 | .019 | 2.91 | 1.19 | 7.09 |
| Prior autoHCT (yes vs no) | .17 | 0.30 | 0.05 | 1.71 | .44 | 0.73 | 0.33 | 1.61 |
| Bridging (yes vs no) | .029 | 4.5 | 1.16 | 17.4 | — | — | — | — |
| Time from indication to CI (> vs < median) | .22 | 2.31 | 0.61 | 8.81 | .50 | 1.32 | 0.60 | 2.88 |
| HCT comorbidity index (>0 vs 0) | .72 | 0.76 | 0.17 | 3.39 | .62 | 0.82 | 0.37 | 1.80 |
| sIPI (HI/H vs L/LI) | .45 | 1.68 | 0.44 | 6.47 | .43 | 1.40 | 0.65 | 3.61 |
| Bulk >10 cm (yes vs no) | .0008 | 23.7 | 3.73 | 151 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .58 | 1.46 | 0.39 | 5.55 | .19 | 1.75 | 0.76 | 4.05 |
| Disease status at conditioning (PD vs CR/PR/SD) | .26 | 2.35 | 0.54 | 10.3 | .57 | 1.37 | 0.46 | 4.04 |
| LDH (> normal vs normal) | .022 | 5.18 | 1.27 | 21.2 | .67 | 0.84 | 0.36 | 1.92 |
| Calendar year of HCT (<2014 vs ≥2014) | — | — | — | — | .71 | 0.81 | 0.39 | 1.90 |
| Donor (related vs unrelated) | — | — | — | — | .099 | 2.08 | 0.87 | 4.98 |
| PFS | ||||||||
| Diagnosis (DLBCL vs other) | .55 | 0.70 | 0.22 | 2.24 | .014 | 0.37 | 0.17 | 0.81 |
| PIF (vs relapse) | .26 | 1.84 | 0.64 | 5.25 | .0078 | 3.59 | 1.40 | 9.22 |
| Prior lines (>3 vs 2-3) | .57 | 1.34 | 0.50 | 3.59 | .023 | 2.63 | 1.14 | 6.01 |
| Prior autoHCT (yes vs no) | .95 | 1.05 | 0.29 | 3.80 | .57 | 0.81 | 0.39 | 1.69 |
| Bridging (yes vs no) | .24 | 1.84 | 0.67 | 5.11 | — | — | — | — |
| Time from indication to CI (> vs < median) | .26 | 1.78 | 0.65 | 4.85 | .88 | 0.95 | 0.45 | 1.97 |
| HCT comorbidity index (>0 vs 0) | .56 | 0.74 | 0.27 | 2.04 | .73 | 1.14 | 0.54 | 2.40 |
| sIPI (HI/H vs L/LI) | .53 | 1.37 | 0.51 | 3.72 | .56 | 1.25 | 0.59 | 2.64 |
| Bulk >10 cm (yes vs no) | .077 | 3.50 | 0.88 | 14.0 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .67 | 0.81 | 0.44 | 1.18 | .14 | 1.82 | 0.83 | 4.00 |
| Disease status at conditioning (PD vs CR/PR/SD) | .064 | 2.68 | 0.95 | 7.60 | .31 | 1.72 | 0.60 | 4.95 |
| LDH at conditioning (> normal vs normal) | .012 | 3.68 | 1.34 | 10.1 | .49 | 0.76 | 0.35 | 1.66 |
| Donor (related vs unrelated) | — | — | — | — | .086 | 2.03 | 0.91 | 4.53 |
| Variable . | CAR T cells . | alloHCT . | ||||||
|---|---|---|---|---|---|---|---|---|
| P . | HR . | Lower CL . | Upper CL . | P . | HR . | Lower CL . | Upper CL . | |
| OS | ||||||||
| Diagnosis (DLBCL vs other) | .59 | 0.66 | 0.15 | 2.97 | .0062 | 0.31 | 0.14 | 0.72 |
| PIF (vs relapse) | .37 | 1.88 | 0.47 | 7.55 | .036 | 2.92 | 1.08 | 7.94 |
| Prior lines (>3 vs 2-3) | .62 | 1.02 | 0.75 | 1.29 | .019 | 2.91 | 1.19 | 7.09 |
| Prior autoHCT (yes vs no) | .17 | 0.30 | 0.05 | 1.71 | .44 | 0.73 | 0.33 | 1.61 |
| Bridging (yes vs no) | .029 | 4.5 | 1.16 | 17.4 | — | — | — | — |
| Time from indication to CI (> vs < median) | .22 | 2.31 | 0.61 | 8.81 | .50 | 1.32 | 0.60 | 2.88 |
| HCT comorbidity index (>0 vs 0) | .72 | 0.76 | 0.17 | 3.39 | .62 | 0.82 | 0.37 | 1.80 |
| sIPI (HI/H vs L/LI) | .45 | 1.68 | 0.44 | 6.47 | .43 | 1.40 | 0.65 | 3.61 |
| Bulk >10 cm (yes vs no) | .0008 | 23.7 | 3.73 | 151 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .58 | 1.46 | 0.39 | 5.55 | .19 | 1.75 | 0.76 | 4.05 |
| Disease status at conditioning (PD vs CR/PR/SD) | .26 | 2.35 | 0.54 | 10.3 | .57 | 1.37 | 0.46 | 4.04 |
| LDH (> normal vs normal) | .022 | 5.18 | 1.27 | 21.2 | .67 | 0.84 | 0.36 | 1.92 |
| Calendar year of HCT (<2014 vs ≥2014) | — | — | — | — | .71 | 0.81 | 0.39 | 1.90 |
| Donor (related vs unrelated) | — | — | — | — | .099 | 2.08 | 0.87 | 4.98 |
| PFS | ||||||||
| Diagnosis (DLBCL vs other) | .55 | 0.70 | 0.22 | 2.24 | .014 | 0.37 | 0.17 | 0.81 |
| PIF (vs relapse) | .26 | 1.84 | 0.64 | 5.25 | .0078 | 3.59 | 1.40 | 9.22 |
| Prior lines (>3 vs 2-3) | .57 | 1.34 | 0.50 | 3.59 | .023 | 2.63 | 1.14 | 6.01 |
| Prior autoHCT (yes vs no) | .95 | 1.05 | 0.29 | 3.80 | .57 | 0.81 | 0.39 | 1.69 |
| Bridging (yes vs no) | .24 | 1.84 | 0.67 | 5.11 | — | — | — | — |
| Time from indication to CI (> vs < median) | .26 | 1.78 | 0.65 | 4.85 | .88 | 0.95 | 0.45 | 1.97 |
| HCT comorbidity index (>0 vs 0) | .56 | 0.74 | 0.27 | 2.04 | .73 | 1.14 | 0.54 | 2.40 |
| sIPI (HI/H vs L/LI) | .53 | 1.37 | 0.51 | 3.72 | .56 | 1.25 | 0.59 | 2.64 |
| Bulk >10 cm (yes vs no) | .077 | 3.50 | 0.88 | 14.0 | — | — | — | — |
| ZUMA-1 ineligible (yes vs no) | .67 | 0.81 | 0.44 | 1.18 | .14 | 1.82 | 0.83 | 4.00 |
| Disease status at conditioning (PD vs CR/PR/SD) | .064 | 2.68 | 0.95 | 7.60 | .31 | 1.72 | 0.60 | 4.95 |
| LDH at conditioning (> normal vs normal) | .012 | 3.68 | 1.34 | 10.1 | .49 | 0.76 | 0.35 | 1.66 |
| Donor (related vs unrelated) | — | — | — | — | .086 | 2.03 | 0.91 | 4.53 |
Bold font indicates significance.
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