Table 1.

Our recommendations for considering a referral to an academic center

Reasons for referralOur suggestions for considering a referral
Diagnostic challenges Diagnosis is challenging, and pathology requests a second opinion. 
Consider referral/expert discussion before palliative treatment, even in elderly patients. 
Treatment challenges Presentation is complex and requires supportive care that is not available at the facility. 
Requires immediate therapy, but potential delays in diagnosis prevent start of therapy 
Consider on the basis of subtype of leukemia Acute promyelocytic leukemia 
Older adults 
Adolescents and young adults with acute lymphoblastic leukemia 
Consider referral for secondary leukemias 
Refractory after one induction 
Relapsed leukemia 
HCT is a consideration. 
Reasons for referralOur suggestions for considering a referral
Diagnostic challenges Diagnosis is challenging, and pathology requests a second opinion. 
Consider referral/expert discussion before palliative treatment, even in elderly patients. 
Treatment challenges Presentation is complex and requires supportive care that is not available at the facility. 
Requires immediate therapy, but potential delays in diagnosis prevent start of therapy 
Consider on the basis of subtype of leukemia Acute promyelocytic leukemia 
Older adults 
Adolescents and young adults with acute lymphoblastic leukemia 
Consider referral for secondary leukemias 
Refractory after one induction 
Relapsed leukemia 
HCT is a consideration. 
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