ORs with 95% CIs for overall VTE and subgroups according to quartiles of VWF plasma levels
| VTE subgroup . | Controls (n = 843) . | Cases . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|---|---|
| Overall VTE | n = 414 | ||||
| VWF Q1 | 210 | 88 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 94 | 1.07 (0.75-1.51) | 1.03 (0.72-1.46) | 1.03 (0.72-1.48) |
| VWF Q3 | 210 | 105 | 1.20 (0.85-1.70) | 1.20 (0.85-1.69) | 1.20 (0.84-1.71) |
| VWF Q4 | 212 | 127 | 1.45 (1.03-2.03) | 1.35 (0.96-1.90) | 1.36 (0.96-1.92) |
| P value for trend | .02 | .05 | .05 | ||
| Provoked VTE | n = 241 | ||||
| VWF Q1 | 210 | 62 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 56 | 0.89 (0.59-1.34) | 0.86 (0.56-1.30) | 0.87 (0.57-1.33) |
| VWF Q3 | 210 | 62 | 0.97 (0.65-1.46) | 0.96 (0.64-1.45) | 0.98 (0.65-1.49) |
| VWF Q4 | 212 | 61 | 0.94 (0.62-1.41) | 0.88 (0.58-1.34) | 0.90 (0.59-1.37) |
| P value for trend | .9 | .7 | .8 | ||
| Unprovoked VTE | n = 173 | ||||
| VWF Q1 | 210 | 26 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 38 | 1.50 (0.88-2.57) | 1.49 (0.86-2.57) | 1.46 (0.84-2.52) |
| VWF Q3 | 210 | 43 | 1.75 (1.03-2.97) | 1.78 (1.04-3.03) | 1.72 (1.00-2.94) |
| VWF Q4 | 212 | 66 | 2.74 (1.66-4.54) | 2.59 (1.55-4.32) | 2.52 (1.51-4.22) |
| P value for trend | <.001 | <.001 | <.001 |
| VTE subgroup . | Controls (n = 843) . | Cases . | Model 1 . | Model 2 . | Model 3 . |
|---|---|---|---|---|---|
| Overall VTE | n = 414 | ||||
| VWF Q1 | 210 | 88 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 94 | 1.07 (0.75-1.51) | 1.03 (0.72-1.46) | 1.03 (0.72-1.48) |
| VWF Q3 | 210 | 105 | 1.20 (0.85-1.70) | 1.20 (0.85-1.69) | 1.20 (0.84-1.71) |
| VWF Q4 | 212 | 127 | 1.45 (1.03-2.03) | 1.35 (0.96-1.90) | 1.36 (0.96-1.92) |
| P value for trend | .02 | .05 | .05 | ||
| Provoked VTE | n = 241 | ||||
| VWF Q1 | 210 | 62 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 56 | 0.89 (0.59-1.34) | 0.86 (0.56-1.30) | 0.87 (0.57-1.33) |
| VWF Q3 | 210 | 62 | 0.97 (0.65-1.46) | 0.96 (0.64-1.45) | 0.98 (0.65-1.49) |
| VWF Q4 | 212 | 61 | 0.94 (0.62-1.41) | 0.88 (0.58-1.34) | 0.90 (0.59-1.37) |
| P value for trend | .9 | .7 | .8 | ||
| Unprovoked VTE | n = 173 | ||||
| VWF Q1 | 210 | 26 | Ref. | Ref. | Ref. |
| VWF Q2 | 211 | 38 | 1.50 (0.88-2.57) | 1.49 (0.86-2.57) | 1.46 (0.84-2.52) |
| VWF Q3 | 210 | 43 | 1.75 (1.03-2.97) | 1.78 (1.04-3.03) | 1.72 (1.00-2.94) |
| VWF Q4 | 212 | 66 | 2.74 (1.66-4.54) | 2.59 (1.55-4.32) | 2.52 (1.51-4.22) |
| P value for trend | <.001 | <.001 | <.001 |
Model 1: adjusted for age and sex. Model 2: model 1 + BMI and CRP. Model 3: model 2 + smoking, hypertension, and estrogen use.
Q, quartile; Ref., reference.