Table 2. Laboratory values in DICER1... | American Society of Hematology

Table 2.

Laboratory values in DICER1 carriers and controls with statistical comparison between the 2 groups

Laboratory tests	Controls (n = 64)				DICER1 carriers (n = 121)				P
	Low		Not low		Low		Not low
	No.	%	No.	%	No.	%	No.	%
Blood count indices
WBCs	2	3	61	97	16	13	104	87	.028*
RBCs	8	13	55	87	7	6	113	94	.108*
Hgb	6	10	57	90	9	8	111	92	.635*
Hematocrit	3	5	62	95	5	4	115	96	1
MCV	1	2	62	98	2	2	118	98	1
MCH	1	2	62	98	1	1	119	99	1
MCHC	5	8	58	92	8	7	112	93	.768
RDW	2	3	61	97	1	1	119	99	.273
Platelet count	5	8	58	92	9	8	110	92	1
MPV	4	6	58	94	16	13	103	87	.154*
Nucleated RBCs	0	0	60	100	0	0	112	100	NA
Absolute nucleated RBCs	0	0	60	100	0	0	112	100	NA
Reticulocytes	2	3	61	96	3	3	117	98	1
Absolute reticulocytes	1	2	62	98	3	3	117	98	1
Reticulocyte Hgb	1	2	62	98	7	7	113	94	.266
Immature platelet fraction	2	3	61	97	6	5	112	95	.716
Immature reticulocyte fraction	4	11	31	89	1	2	67	99	.044
Differentials
Absolute neutrophil count	1	2	62	98	10	8	110	92	.101
Absolute immature granulocytes	0	0	51	100	0	0	89	100	NA
Absolute lymphocytes	3	5	60	95	8	7	112	93	.751
Absolute monocytes	2	3	61	97	5	4	115	96	1
Absolute eosinophils	0	0	63	100	7	6	113	94	.097
Absolute basophils	3	5	60	95	7	6	113	94	1
Iron indices
Iron	2	14	12	86	3	10	26	90	1
Transferrin	0	0	14	100	0	0	29	100	NA
Iron saturation	4	29	10	71	11	38	18	62	.735
Ferritin	6	10	57	90	26	22	94	78	.040*
Other indices
Erythrocyte sedimentation rate	0	0	42	100	0	0	76	100	NA
Fetal Hgb	0	0	52	100	0	0	101	100	NA
Erythropoietin	0	0	56	100	0	0	104	100	NA
Lactate dehydrogenase	0	0	61	100	3	3	114	97	.552

Laboratory tests	Controls (n = 64)				DICER1 carriers (n = 121)				P
	Low		Not low		Low		Not low
	No.	%	No.	%	No.	%	No.	%
Blood count indices
WBCs	2	3	61	97	16	13	104	87	.028*
RBCs	8	13	55	87	7	6	113	94	.108*
Hgb	6	10	57	90	9	8	111	92	.635*
Hematocrit	3	5	62	95	5	4	115	96	1
MCV	1	2	62	98	2	2	118	98	1
MCH	1	2	62	98	1	1	119	99	1
MCHC	5	8	58	92	8	7	112	93	.768
RDW	2	3	61	97	1	1	119	99	.273
Platelet count	5	8	58	92	9	8	110	92	1
MPV	4	6	58	94	16	13	103	87	.154*
Nucleated RBCs	0	0	60	100	0	0	112	100	NA
Absolute nucleated RBCs	0	0	60	100	0	0	112	100	NA
Reticulocytes	2	3	61	96	3	3	117	98	1
Absolute reticulocytes	1	2	62	98	3	3	117	98	1
Reticulocyte Hgb	1	2	62	98	7	7	113	94	.266
Immature platelet fraction	2	3	61	97	6	5	112	95	.716
Immature reticulocyte fraction	4	11	31	89	1	2	67	99	.044
Differentials
Absolute neutrophil count	1	2	62	98	10	8	110	92	.101
Absolute immature granulocytes	0	0	51	100	0	0	89	100	NA
Absolute lymphocytes	3	5	60	95	8	7	112	93	.751
Absolute monocytes	2	3	61	97	5	4	115	96	1
Absolute eosinophils	0	0	63	100	7	6	113	94	.097
Absolute basophils	3	5	60	95	7	6	113	94	1
Iron indices
Iron	2	14	12	86	3	10	26	90	1
Transferrin	0	0	14	100	0	0	29	100	NA
Iron saturation	4	29	10	71	11	38	18	62	.735
Ferritin	6	10	57	90	26	22	94	78	.040*
Other indices
Erythrocyte sedimentation rate	0	0	42	100	0	0	76	100	NA
Fetal Hgb	0	0	52	100	0	0	101	100	NA
Erythropoietin	0	0	56	100	0	0	104	100	NA
Lactate dehydrogenase	0	0	61	100	3	3	114	97	.552

Percentages may not sum to 100% due to rounding. P values < .05 are shown in bold.

MCH, mean corpuscular Hgb; MCHC, mean corpuscular Hgb concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; NA, not applicable; RDW, red blood cell distribution width.

Indicates χ² test instead of Fisher’s exact test.

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