Pathological findings of ATLL with HTLV-1–infected HRS-like cells: morphology and immunophenotype
| . | Morphology . | Immunophenotype of HRS-like cells . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case . | Tissue . | Architecture . | Sclerosis . | CD30 . | CD15 . | CD3 . | CD4 . | CD5 . | CD7 . | CD8 . | CD25 . | PAX5 . | CD20 . | PD-L1 . |
| 1 | Cervical LN | Diffuse | + | + | + | − | +, f | − | − | − | + | − | − | +, f |
| 2 | Axillary LN | Partial infiltration | − | + | + | − | + | − | − | − | + | − | − | + |
| 3 | Mediastinal mass | Nodular | + | + | +, f | − | − | − | − | − | + | − | − | +, f |
| 4 | Cervical LN | Diffuse | − | + | + | − | + | − | − | − | + | − | − | − |
| 5 | Cervical LN | Diffuse | − | + | +, f | − | − | − | − | − | + | − | − | − |
| 6 | Cervical LN | Nodular | + | + | + | − | − | − | − | − | + | − | − | − |
| 7 | Inguinal LN | Diffuse | − | + | +, f | − | + | − | − | − | + | − | − | + |
| 8 | Supraclavicular LN | Diffuse | + | + | +, f | − | +, f | − | − | − | + | − | − | +, f |
| . | Morphology . | Immunophenotype of HRS-like cells . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case . | Tissue . | Architecture . | Sclerosis . | CD30 . | CD15 . | CD3 . | CD4 . | CD5 . | CD7 . | CD8 . | CD25 . | PAX5 . | CD20 . | PD-L1 . |
| 1 | Cervical LN | Diffuse | + | + | + | − | +, f | − | − | − | + | − | − | +, f |
| 2 | Axillary LN | Partial infiltration | − | + | + | − | + | − | − | − | + | − | − | + |
| 3 | Mediastinal mass | Nodular | + | + | +, f | − | − | − | − | − | + | − | − | +, f |
| 4 | Cervical LN | Diffuse | − | + | + | − | + | − | − | − | + | − | − | − |
| 5 | Cervical LN | Diffuse | − | + | +, f | − | − | − | − | − | + | − | − | − |
| 6 | Cervical LN | Nodular | + | + | + | − | − | − | − | − | + | − | − | − |
| 7 | Inguinal LN | Diffuse | − | + | +, f | − | + | − | − | − | + | − | − | + |
| 8 | Supraclavicular LN | Diffuse | + | + | +, f | − | +, f | − | − | − | + | − | − | +, f |
f, focal (10%-30% of cells positive); LN, lymph node.