Second allo-HSCT
| . | . | First allo-HSCT . | Second allo-HSCT . | . | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex . | LAD type . | Age at HSCT, mo . | Source, HLA-matching . | Donor . | Conditioning . | Serotherapy . | GVHD prophylaxis . | Engraftment, d . | aGVHD grade . | GF, mo . | 2nd HSCT, mo . | Source, HLA-matching . | Donor . | Conditioning . | Serotherapy . | GVHD prophylaxis . | Engraftment, d . | GF, mo . | aGVHD grade . | LFU since 1st allo-HSCT, mo . |
| M | I | 19 | PB, <9/10 | MMFD (haplo) | Treo + Flu + TT | Alemtuzumab | No GVHD prevention | No | — | PGF | +1 | PB, <9/10 | MMFD | Flu + Cy + TBI | ATG | No GVHD prevention | Yes, +32 | No | I | Alive, +6 |
| M | III | 25 | CB, <5/6 | MMUD | Bu + Flu | ATG | CSA + MMF | No | — | PGF | +1 | CB, <5/6 | MMUD | n.a. | CSA + MMF | No | PGF | 0 | Dead, +4 | |
| F | I | 4 | n.a. | MSD | Bu + Flu | ATG | n.a. | Yes, +14 | SGF, +9 | +11 | n.a. | MSD | Treo + Flu | No | n.a. | n.a. | n.a. | n.a. | Alive, +25 | |
| F | I | 36 | n.a. | MSD | Mel + Flu | ATG | CSA + corticosteroids | Yes, +14 | II | SGF, +71 | +86 | BM, 10/10 | MSD | Treo + Flu + TT | No | CSA + MTX | Yes, +19 | No | I | Alive, +121 |
| M | I | 14 | BM, 10/10 | MSD | Treo + Flu | ATG | CSA | Yes, +17 | III | SGF, +12 | +15 | BM, 10/10 | MSD | n.a. | n.a. | Yes, +14 | No | 0 | Alive, +31 | |
| M | I | 16 | CB, 6/6 | MUD | Bu + Flu | ATG | CSA | Yes, +25 | 0 | SGF, +1 | +5 | PB, 10/10 | MUD | Treo + Flu | Alemtuzumab | CSA + MMF | Yes, +9 | No | 0 | Alive, +54 |
| F | Other | 12 | BM, 10/10 | MUD | Bu + Flu + TT | ATG | CSA + MMF | Yes, +43 | 0 | SGF, +3 | +5 | PB, 10/10 | MUD | n.a. | No | Other | Yes, +16 | No | II | Alive, +30 |
| M | I | 23 | BM, 10/10 | MUD | Bu + Cy | ATG | CSA + corticosteroids | Yes, +49 | I | SGF, +2 | +14 | PB, <9/10 | MMUD | Mel + Flu | Alemtuzumab | Other | Yes, +17 | SGF, +4 | 0 | Dead, +26 |
| M | I | 354 | BM, 10/10 | MUD | Treo + Flu | ATG | CSA + MTX | Yes, +22 | 0 | SGF, +3 | +13 | PB, 10/10 | MUD | Treo + Flu + TT | ATG | CSA + MTX | Yes, +23 | No | 0 | Alive, +16 |
| M | I | 24 | PB, 10/10 | MUD | Treo + Flu | ATG | CSA + MTX | Yes, +27 | 0 | SGF, +2 | +5 | BM, 10/10 | MUD | Bu + Flu + TT | ATG | CSA + MTX | Yes, +24 | No | 0 | Alive, +29 |
| M | I | 14 | PB, <9/10 | MMUD | Treo + Flu | ATG | Other | Yes, +18 | 0 | SGF, +6 | +6 | BM, <9/10 | MMUD | Flu + Cy | ATG | Other | Yes, +8 | No | 0 | Alive, +19 |
| M | I | 5 | CB, 5/6 | MMUD | Bu + Cy | ATG | CSA + corticosteroids | Yes, +34 | 0 | SGF, +8 | +8 | CB n.a. | n.a. | Cy + TBI | ATG | CSA + corticosteroids | Yes, +35 | No | 0 | Alive, +55 |
| F | I | 8 | CB, <5/6 | MMUD | Treo + Flu | ATG | CSA | Yes, +27 | 0 | SGF, +43 | +95 | PB, <9/10 | MMUD | Mel + Flu | Alemtuzumab | CSA + MMF | Yes, +20 | SGF, +32 | I | Alive, +128 |
| F | III | 22 | CB, 5/6 | MMUD | Bu + Cy | ATG | CSA + MMF | Yes, +16 | 0 | SGF, +1 | +27 | BM, <9/10 | MMUD | Treo + Flu + TT | ATG | CSA + MMF | Yes, +14 | No | IV | Alive, +78 |
| F | III | 44 | PB, <9/10 | MMFD | Mel + Flu + TT | ATG | No GVHD prevention | Yes, +9 | 0 | SGF, +2 | +2 | PB, <9/10 | MMFD | Bu + Cy + TBI | No | No GVHD prevention | n.a. | SGF, +3 | 0 | Alive, +5 |
| . | . | First allo-HSCT . | Second allo-HSCT . | . | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex . | LAD type . | Age at HSCT, mo . | Source, HLA-matching . | Donor . | Conditioning . | Serotherapy . | GVHD prophylaxis . | Engraftment, d . | aGVHD grade . | GF, mo . | 2nd HSCT, mo . | Source, HLA-matching . | Donor . | Conditioning . | Serotherapy . | GVHD prophylaxis . | Engraftment, d . | GF, mo . | aGVHD grade . | LFU since 1st allo-HSCT, mo . |
| M | I | 19 | PB, <9/10 | MMFD (haplo) | Treo + Flu + TT | Alemtuzumab | No GVHD prevention | No | — | PGF | +1 | PB, <9/10 | MMFD | Flu + Cy + TBI | ATG | No GVHD prevention | Yes, +32 | No | I | Alive, +6 |
| M | III | 25 | CB, <5/6 | MMUD | Bu + Flu | ATG | CSA + MMF | No | — | PGF | +1 | CB, <5/6 | MMUD | n.a. | CSA + MMF | No | PGF | 0 | Dead, +4 | |
| F | I | 4 | n.a. | MSD | Bu + Flu | ATG | n.a. | Yes, +14 | SGF, +9 | +11 | n.a. | MSD | Treo + Flu | No | n.a. | n.a. | n.a. | n.a. | Alive, +25 | |
| F | I | 36 | n.a. | MSD | Mel + Flu | ATG | CSA + corticosteroids | Yes, +14 | II | SGF, +71 | +86 | BM, 10/10 | MSD | Treo + Flu + TT | No | CSA + MTX | Yes, +19 | No | I | Alive, +121 |
| M | I | 14 | BM, 10/10 | MSD | Treo + Flu | ATG | CSA | Yes, +17 | III | SGF, +12 | +15 | BM, 10/10 | MSD | n.a. | n.a. | Yes, +14 | No | 0 | Alive, +31 | |
| M | I | 16 | CB, 6/6 | MUD | Bu + Flu | ATG | CSA | Yes, +25 | 0 | SGF, +1 | +5 | PB, 10/10 | MUD | Treo + Flu | Alemtuzumab | CSA + MMF | Yes, +9 | No | 0 | Alive, +54 |
| F | Other | 12 | BM, 10/10 | MUD | Bu + Flu + TT | ATG | CSA + MMF | Yes, +43 | 0 | SGF, +3 | +5 | PB, 10/10 | MUD | n.a. | No | Other | Yes, +16 | No | II | Alive, +30 |
| M | I | 23 | BM, 10/10 | MUD | Bu + Cy | ATG | CSA + corticosteroids | Yes, +49 | I | SGF, +2 | +14 | PB, <9/10 | MMUD | Mel + Flu | Alemtuzumab | Other | Yes, +17 | SGF, +4 | 0 | Dead, +26 |
| M | I | 354 | BM, 10/10 | MUD | Treo + Flu | ATG | CSA + MTX | Yes, +22 | 0 | SGF, +3 | +13 | PB, 10/10 | MUD | Treo + Flu + TT | ATG | CSA + MTX | Yes, +23 | No | 0 | Alive, +16 |
| M | I | 24 | PB, 10/10 | MUD | Treo + Flu | ATG | CSA + MTX | Yes, +27 | 0 | SGF, +2 | +5 | BM, 10/10 | MUD | Bu + Flu + TT | ATG | CSA + MTX | Yes, +24 | No | 0 | Alive, +29 |
| M | I | 14 | PB, <9/10 | MMUD | Treo + Flu | ATG | Other | Yes, +18 | 0 | SGF, +6 | +6 | BM, <9/10 | MMUD | Flu + Cy | ATG | Other | Yes, +8 | No | 0 | Alive, +19 |
| M | I | 5 | CB, 5/6 | MMUD | Bu + Cy | ATG | CSA + corticosteroids | Yes, +34 | 0 | SGF, +8 | +8 | CB n.a. | n.a. | Cy + TBI | ATG | CSA + corticosteroids | Yes, +35 | No | 0 | Alive, +55 |
| F | I | 8 | CB, <5/6 | MMUD | Treo + Flu | ATG | CSA | Yes, +27 | 0 | SGF, +43 | +95 | PB, <9/10 | MMUD | Mel + Flu | Alemtuzumab | CSA + MMF | Yes, +20 | SGF, +32 | I | Alive, +128 |
| F | III | 22 | CB, 5/6 | MMUD | Bu + Cy | ATG | CSA + MMF | Yes, +16 | 0 | SGF, +1 | +27 | BM, <9/10 | MMUD | Treo + Flu + TT | ATG | CSA + MMF | Yes, +14 | No | IV | Alive, +78 |
| F | III | 44 | PB, <9/10 | MMFD | Mel + Flu + TT | ATG | No GVHD prevention | Yes, +9 | 0 | SGF, +2 | +2 | PB, <9/10 | MMFD | Bu + Cy + TBI | No | No GVHD prevention | n.a. | SGF, +3 | 0 | Alive, +5 |
LFU, last follow-up; TBI, total body irradiation.