Table 1. Diagnosis and classification of... | American Society of Hematology

Table 1.

Diagnosis and classification of ATL

Subtype	Asymptomatic HTLV-1 carrier	Smoldering	Chronic	Acute	Lymphoma
HTLV-1 serology	+	+	+	+	+
Monoclonal integration of provirus	−	+	+	+	+ (lymph node)
Lymphocyte count	Normal	Normal	Elevated	Elevated	Normal
Percentage circulating abnormal lymphocytes	<5%	≥5% or <5% if ATL skin and lung lesions present	≥5%	≥5%	≤1%
Hypercalcemia	−	−	−	Normal or high	Normal or high
LDH	Normal	Normal or ≤1.5 ULN	Normal or <2 ULN	Normal or high	Normal or high
Skin or lung involvement	−	+	+	+	+
Bone marrow or splenic involvement	−	−	+	+	+
Bone, gastrointestinal, or CNS involvement	−	−	−	+	+

Subtype	Asymptomatic HTLV-1 carrier	Smoldering	Chronic	Acute	Lymphoma
HTLV-1 serology	+	+	+	+	+
Monoclonal integration of provirus	−	+	+	+	+ (lymph node)
Lymphocyte count	Normal	Normal	Elevated	Elevated	Normal
Percentage circulating abnormal lymphocytes	<5%	≥5% or <5% if ATL skin and lung lesions present	≥5%	≥5%	≤1%
Hypercalcemia	−	−	−	Normal or high	Normal or high
LDH	Normal	Normal or ≤1.5 ULN	Normal or <2 ULN	Normal or high	Normal or high
Skin or lung involvement	−	+	+	+	+
Bone marrow or splenic involvement	−	−	+	+	+
Bone, gastrointestinal, or CNS involvement	−	−	−	+	+

−, negative; +, positive; CNS, central nervous system; ULN, upper limit of normal.