Univariate analysis of prespecified parameters for OS and PFS
| Covariate . | Group . | OS . | PFS . | ||
|---|---|---|---|---|---|
| P . | HR (95% CI) . | P . | HR (95% CI) . | ||
| Age | <60 y | 1.00 | 1.00 | ||
| >60 y | .025 | 1.41 (0.94-2.12) | .120 | 1.28 (0.87-1.87) | |
| Disease stage | I-II | 1.00 | 1.00 | ||
| III-IV | .005 | 1.85 (1.18-2.91) | .01 | 1.72 (1.13-2.63) | |
| B symptoms | No | 1.00 | 1.00 | ||
| Yes | .002 | 1.94 (1.30-2.89) | .001 | 2.07 (1.41-3.08) | |
| Bone marrow involvement | No | 1.00 | 1.00 | ||
| Yes | .282 | 1.44 (0.72-2.87) | .11 | 1.75 (0.91-3.37) | |
| CRP | <ULN | 1.00 | 1.00 | ||
| >ULN | .113 | 1.69 (0.90-3.19) | .05 | 1.36 (0.99-1.54) | |
| Platelet count | <150 × 109 | 1.00 | 1.00 | ||
| >150 × 109 | .014 | 2.29 (1.29-4.05) | .063 | 1.99 (1.13-3.51) | |
| LDH | <ULN | 1.00 | 1.00 | ||
| >ULN | .001 | 2.73 (1.77-4.19) | .001 | 2.34 (1.57-3.49) | |
| ECOG-PS | ≥2 | 1.00 | 1.00 | ||
| ≤2 | .001 | 3.23 (2.14-4.89) | .001 | 2.71 (1.82-4.04) | |
| Covariate . | Group . | OS . | PFS . | ||
|---|---|---|---|---|---|
| P . | HR (95% CI) . | P . | HR (95% CI) . | ||
| Age | <60 y | 1.00 | 1.00 | ||
| >60 y | .025 | 1.41 (0.94-2.12) | .120 | 1.28 (0.87-1.87) | |
| Disease stage | I-II | 1.00 | 1.00 | ||
| III-IV | .005 | 1.85 (1.18-2.91) | .01 | 1.72 (1.13-2.63) | |
| B symptoms | No | 1.00 | 1.00 | ||
| Yes | .002 | 1.94 (1.30-2.89) | .001 | 2.07 (1.41-3.08) | |
| Bone marrow involvement | No | 1.00 | 1.00 | ||
| Yes | .282 | 1.44 (0.72-2.87) | .11 | 1.75 (0.91-3.37) | |
| CRP | <ULN | 1.00 | 1.00 | ||
| >ULN | .113 | 1.69 (0.90-3.19) | .05 | 1.36 (0.99-1.54) | |
| Platelet count | <150 × 109 | 1.00 | 1.00 | ||
| >150 × 109 | .014 | 2.29 (1.29-4.05) | .063 | 1.99 (1.13-3.51) | |
| LDH | <ULN | 1.00 | 1.00 | ||
| >ULN | .001 | 2.73 (1.77-4.19) | .001 | 2.34 (1.57-3.49) | |
| ECOG-PS | ≥2 | 1.00 | 1.00 | ||
| ≤2 | .001 | 3.23 (2.14-4.89) | .001 | 2.71 (1.82-4.04) | |
HR, hazard ratio.