Circulating levels of angiopoietin-1, angiopoietin-2, Tie2, vWF, and endoglin in patients who were survivors and nonsurvivors of COVID-19
| Biomarkers . | Status . | Derivation cohort . | Validation cohort . | ||||
|---|---|---|---|---|---|---|---|
| Mean . | Standard deviation . | P . | Mean . | Standard deviation . | P . | ||
| Angiopoietin-1, pg/mL | Nonsurvivor | 20.083 | 7.168 | .882 | 16.518 | 12.243 | .914 |
| Survivor | 19.148 | 11.520 | 17.078 | 12.243 | |||
| Angiopoietin-2, pg/mL | Nonsurvivor | 2.765 | 2.455 | .246 | 1.808 | 0.879 | .424 |
| Survivor | 2.125 | 1.855 | 2.156 | 1.628 | |||
| Angiopoietin-2/angiopoietin-1 | Nonsurvivor | 0.383 | 0.210 | .007 | 0.298 | 0.260 | .040 |
| Survivor | 0.084 | 0.015 | 0.159 | 0.128 | |||
| Tie2, pg/mL | Nonsurvivor | 18.608 | 7.830 | .883 | 19.803 | 8.987 | .766 |
| Survivor | 19.772 | 9.169 | 20.518 | 7.732 | |||
| vWF, ng/mL | Nonsurvivor | 283.7 | 17.5 | .395 | NA | NA | NA |
| Survivor | 266.4 | 40.1 | NA | NA | NA | ||
| Endoglin, pg/mL | Nonsurvivor | 2.535 | 689 | .660 | 2.533 | 788 | .293 |
| Survivor | 1.937 | 447 | 2.284 | 783 | |||
| Biomarkers . | Status . | Derivation cohort . | Validation cohort . | ||||
|---|---|---|---|---|---|---|---|
| Mean . | Standard deviation . | P . | Mean . | Standard deviation . | P . | ||
| Angiopoietin-1, pg/mL | Nonsurvivor | 20.083 | 7.168 | .882 | 16.518 | 12.243 | .914 |
| Survivor | 19.148 | 11.520 | 17.078 | 12.243 | |||
| Angiopoietin-2, pg/mL | Nonsurvivor | 2.765 | 2.455 | .246 | 1.808 | 0.879 | .424 |
| Survivor | 2.125 | 1.855 | 2.156 | 1.628 | |||
| Angiopoietin-2/angiopoietin-1 | Nonsurvivor | 0.383 | 0.210 | .007 | 0.298 | 0.260 | .040 |
| Survivor | 0.084 | 0.015 | 0.159 | 0.128 | |||
| Tie2, pg/mL | Nonsurvivor | 18.608 | 7.830 | .883 | 19.803 | 8.987 | .766 |
| Survivor | 19.772 | 9.169 | 20.518 | 7.732 | |||
| vWF, ng/mL | Nonsurvivor | 283.7 | 17.5 | .395 | NA | NA | NA |
| Survivor | 266.4 | 40.1 | NA | NA | NA | ||
| Endoglin, pg/mL | Nonsurvivor | 2.535 | 689 | .660 | 2.533 | 788 | .293 |
| Survivor | 1.937 | 447 | 2.284 | 783 | |||
NA, not available.