Characteristics of the study population
| Characteristic . | HU-naïve patients (n = 23) . | HU-exposed patients (n = 15) . | P* . | ||||
|---|---|---|---|---|---|---|---|
| No. (%) . | Median (range) . | Percentage of patients with abnormal values . | No. (%) . | Median (range) . | Percentage of patients with abnormal values . | ||
| Acute chest syndrome (episodesin the year preceding thesemen analysis) | 1.0 (0-5) | 3 (0-14.0) | .0330 | ||||
| Hospitalizations for vaso-occlusive events (in the year preceding the semen analysis) | 1.0 (0-7.0) | 1.5 (0-5.0) | .7305 | ||||
| Age at the time of the semen analysis, y | 20 (16-24) | 17 (16-23) | .0048 | ||||
| Treatment | |||||||
| Age at HU initiation, y | — | 6.0 (1.0-14.0) | |||||
| Duration of HU treatment before the semen analysis, y | — | 4.0 (0.5-10.0) | |||||
| Wash-out period, y | — | 2.5 (0-13.0) | |||||
| In a transfusion program at the time of the semen analysis,n (%) | 12 (52) | 15 (100) | .0052 | ||||
| Transfusion program duration before the semenanalysis, y | 0 (0-8.0) | 3 (0-13.0) | .0228 | ||||
| Indication for HU | |||||||
| Acute chest syndrome orvaso-occlusive events | — | 6 | |||||
| Vasculopathy | — | 7 | |||||
| Anemia | — | 2 | |||||
| Indication for transfusion | 12 (52) | 15 (100) | |||||
| Vasculopathy | 1 | 6 | |||||
| Recurrent acute chestsyndrome/vaso-occlusive event | 9 | 6 | |||||
| Sperm banking | 2 | 2 | |||||
| Anemia | — | 1 | |||||
| Sperm parameters | |||||||
| Semen volume (mL) | 46 | 2.0 (0.25-5.90) | 36.96 | 26 | 2.7 (0.20-10.35) | 26.92 | .5265 |
| Sperm concentration (106/mL) | 46 | 8.0 (0.00-120.00) | 56.52 | 26 | 25.3 (0.00-210.00) | 50.00 | .3952 |
| Total sperm count (×106) | 45 | 12.0 (0.00-523.90) | 64.44 | 22 | 77.5 (0.40-525.00) | 40.91 | .0625 |
| Progressive motility (% of spermatozoa) | 46 | 35.0 (1.00-55.00) | 45.65 | 26 | 32.0 (0.00-75.00) | 50.00 | .4541 |
| Typical forms (% of spermatozoa) | 25 | 9.5 (0.00-38.00) | 88.00 | 16 | 6.0 (0.00-25.00) | 93.75 | .2081 |
| Vitality (% of live spermatozoa) | 39 | 58.0 (0.00-87.00) | 48.72 | 22 | 52.5 (12.00-77.00) | 59.09 | .4396 |
| Sexual abstinence, d | 28 | 5.0 (2.00-30.00) | 14.29 | 24 | 6.0 (2.00-90.00) | 33.33 | .1860 |
| Characteristic . | HU-naïve patients (n = 23) . | HU-exposed patients (n = 15) . | P* . | ||||
|---|---|---|---|---|---|---|---|
| No. (%) . | Median (range) . | Percentage of patients with abnormal values . | No. (%) . | Median (range) . | Percentage of patients with abnormal values . | ||
| Acute chest syndrome (episodesin the year preceding thesemen analysis) | 1.0 (0-5) | 3 (0-14.0) | .0330 | ||||
| Hospitalizations for vaso-occlusive events (in the year preceding the semen analysis) | 1.0 (0-7.0) | 1.5 (0-5.0) | .7305 | ||||
| Age at the time of the semen analysis, y | 20 (16-24) | 17 (16-23) | .0048 | ||||
| Treatment | |||||||
| Age at HU initiation, y | — | 6.0 (1.0-14.0) | |||||
| Duration of HU treatment before the semen analysis, y | — | 4.0 (0.5-10.0) | |||||
| Wash-out period, y | — | 2.5 (0-13.0) | |||||
| In a transfusion program at the time of the semen analysis,n (%) | 12 (52) | 15 (100) | .0052 | ||||
| Transfusion program duration before the semenanalysis, y | 0 (0-8.0) | 3 (0-13.0) | .0228 | ||||
| Indication for HU | |||||||
| Acute chest syndrome orvaso-occlusive events | — | 6 | |||||
| Vasculopathy | — | 7 | |||||
| Anemia | — | 2 | |||||
| Indication for transfusion | 12 (52) | 15 (100) | |||||
| Vasculopathy | 1 | 6 | |||||
| Recurrent acute chestsyndrome/vaso-occlusive event | 9 | 6 | |||||
| Sperm banking | 2 | 2 | |||||
| Anemia | — | 1 | |||||
| Sperm parameters | |||||||
| Semen volume (mL) | 46 | 2.0 (0.25-5.90) | 36.96 | 26 | 2.7 (0.20-10.35) | 26.92 | .5265 |
| Sperm concentration (106/mL) | 46 | 8.0 (0.00-120.00) | 56.52 | 26 | 25.3 (0.00-210.00) | 50.00 | .3952 |
| Total sperm count (×106) | 45 | 12.0 (0.00-523.90) | 64.44 | 22 | 77.5 (0.40-525.00) | 40.91 | .0625 |
| Progressive motility (% of spermatozoa) | 46 | 35.0 (1.00-55.00) | 45.65 | 26 | 32.0 (0.00-75.00) | 50.00 | .4541 |
| Typical forms (% of spermatozoa) | 25 | 9.5 (0.00-38.00) | 88.00 | 16 | 6.0 (0.00-25.00) | 93.75 | .2081 |
| Vitality (% of live spermatozoa) | 39 | 58.0 (0.00-87.00) | 48.72 | 22 | 52.5 (12.00-77.00) | 59.09 | .4396 |
| Sexual abstinence, d | 28 | 5.0 (2.00-30.00) | 14.29 | 24 | 6.0 (2.00-90.00) | 33.33 | .1860 |
Mann-Whitney U test.