Table 2.

Primary and secondary outcomes according to the treatment regimen

OutcomeTriplet regimen (N = 90)Historical cohort (N = 180)P
Primary outcome    
 Composite of death and refractoriness    
  All patients 2 (2.2%) 22 (12.2%)* .01 
 According to French Severity score    
  0-2 2 (2.8%) 15 (8.3%) <.01 
  3-4 7 (33%)  
Secondary outcomes    
 Death 1 (1.1%) 12 (6.7%) .06 
 Refractoriness 1 (1.1%) 16 (18%) .01 
 Exacerbations 3 (3.4%) 70 (44%) <.01 
 Time to durable platelet count recovery 5 (4-6) 12 (6-17) <.01 
 Number of daily TPE until remission 5 (4-7) 10 (6-16) <.01 
 Volume of plasma (L) until remission 24.2 (18.3-30.2) 44.4 (26.3-74.3) <.01 
 Time to ADAMTS13 activity > 20% (days) 28 (14-42) 48 (24-83) <.01 
 Length of hospitalization (days) 13 (9-19) 22 (15-30) .01 
 Thromboembolic events 11 (12%) 20 (11.1%) .79 
OutcomeTriplet regimen (N = 90)Historical cohort (N = 180)P
Primary outcome    
 Composite of death and refractoriness    
  All patients 2 (2.2%) 22 (12.2%)* .01 
 According to French Severity score    
  0-2 2 (2.8%) 15 (8.3%) <.01 
  3-4 7 (33%)  
Secondary outcomes    
 Death 1 (1.1%) 12 (6.7%) .06 
 Refractoriness 1 (1.1%) 16 (18%) .01 
 Exacerbations 3 (3.4%) 70 (44%) <.01 
 Time to durable platelet count recovery 5 (4-6) 12 (6-17) <.01 
 Number of daily TPE until remission 5 (4-7) 10 (6-16) <.01 
 Volume of plasma (L) until remission 24.2 (18.3-30.2) 44.4 (26.3-74.3) <.01 
 Time to ADAMTS13 activity > 20% (days) 28 (14-42) 48 (24-83) <.01 
 Length of hospitalization (days) 13 (9-19) 22 (15-30) .01 
 Thromboembolic events 11 (12%) 20 (11.1%) .79 

Data are given as median (25th-75th percentile) for quantitative variables and as n (%) for qualitative variables. Patients at high risk of early death of iTTP were defined by a French severity score ≥ 3 (cerebral involvement: yes = 1/no = 0, LDH: >10×ULN = 1/≤10×ULN = 0, age: >60 y = 2/>40 and ≤60 y = 1/≤40 y = 0).12 

*

Includes 10 refractory patients who survived (only 1 event per patient was considered).

Includes 6 deaths.

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