Table 4. Patient outcome according to... | American Society of Hematology

Table 4.

Patient outcome according to random assignment for lenalidomide maintenance or observation

	Observation	Lenalidomide maintenance	Cox regression*
	Observation	Lenalidomide maintenance	HR	95% CI	P
Total	43 (100)	45 (100)
Outcomes
Relapse after second randomization	12 (28)	11 (24)
Death after second randomization	8 (19)	4 (9)
Relapse-free mortality after second randomization	2 (5)	—
At 3 years (% ± SE):
CIR†	34 ± 10	28 ± 8	0.81	0.36-1.85	.62
RFS†	67 ± 7	75 ± 6	0.70	0.32-1.55	.38
OS†	84 ± 6	91 ± 4	0.51	0.15-1.72	.28
MRD positive
Before second randomization	2 (5)	4 (9)
After second randomization	2 (5)	1 (2)

	Observation	Lenalidomide maintenance	Cox regression*
	Observation	Lenalidomide maintenance	HR	95% CI	P
Total	43 (100)	45 (100)
Outcomes
Relapse after second randomization	12 (28)	11 (24)
Death after second randomization	8 (19)	4 (9)
Relapse-free mortality after second randomization	2 (5)	—
At 3 years (% ± SE):
CIR†	34 ± 10	28 ± 8	0.81	0.36-1.85	.62
RFS†	67 ± 7	75 ± 6	0.70	0.32-1.55	.38
OS†	84 ± 6	91 ± 4	0.51	0.15-1.72	.28
MRD positive
Before second randomization	2 (5)	4 (9)
After second randomization	2 (5)	1 (2)

Data are n (%) unless otherwise stated.

Cox regression included maintenance treatment arm, induction treatment arm, and type of consolidation treatment as covariates.

Percentages are actuarial 3-year probabilities.