Table 1. Summary of PK parameters .... | American Society of Hematology

Table 1.

Summary of PK parameters

	rhFVIII	rhFVIII + VWF-12	rhFVIII + VWF-13
Application route	IV	SC	SC
rhFVIII dose, IU/kg	200	1000	1000
c_max, IU/dL	114.1	53.8	25.6
t_max, h	1	6	6
t_1/2, h	2.8	7.2	2.8
AUC, IU × h/dL	838.7	773.6	303.1
F, %	—	18.5	7.2

	rhFVIII	rhFVIII + VWF-12	rhFVIII + VWF-13
Application route	IV	SC	SC
rhFVIII dose, IU/kg	200	1000	1000
c_max, IU/dL	114.1	53.8	25.6
t_max, h	1	6	6
t_1/2, h	2.8	7.2	2.8
AUC, IU × h/dL	838.7	773.6	303.1
F, %	—	18.5	7.2

—, not applicable; AUC, area under the concentration curve; c_max, peak concentration; F, bioavailability; SC, subcutaneous; t_1/2, apparent half-life; t_max, time to concentration peak.

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