Patient characteristics
| Items . | Entire cohort (N = 136), no. (%) . | IL-6+ leukocytes, no. (%) . | P . | |
|---|---|---|---|---|
| ≥1% (n = 54) . | <1% (n = 82) . | |||
| Age, y | .02 | |||
| ≥45 | 40 (29) | 22 (41) | 18 (22) | |
| <45 | 96 (71) | 32 (59) | 64 (78) | |
| Missing | 0 (0) | 0 (0) | 0 (0) | |
| Sex | .98 | |||
| Male | 81 (60) | 32 (60) | 49 (60) | |
| Female | 55 (40) | 22 (40) | 33 (40) | |
| Missing | 0 (0) | 0 (0) | 0 (0) | |
| Stage | .07 | |||
| IA-IIA | 57 (42) | 17 (31) | 40 (49) | |
| IIB-IVB | 77 (57) | 36 (67) | 41 (50) | |
| Missing | 2 (1) | 1 (2) | 1 (1) | |
| B symptoms | .01 | |||
| Yes | 62 (46) | 32 (59) | 30 (37) | |
| No | 72 (53) | 21 (39) | 51 (62) | |
| Missing | 2 (1) | 1 (2) | 1 (1) | |
| IPS | .05 | |||
| >2 | 24 (18) | 15 (28) | 9 (11) | |
| <2 | 78 (57) | 29 (54) | 49 (60) | |
| Missing | 34 (25) | 10 (18) | 24 (29) | |
| EBV | .25 | |||
| Yes | 32 (24) | 16 (30) | 16 (20) | |
| No | 101 (74) | 37 (69) | 64 (78) | |
| Missing | 3 (2) | 1 (1) | 2 (2) | |
| ESR, ≥50 mm/h | <.01 | |||
| Yes | 53 (39) | 28 (52) | 25 (30) | |
| No | 71 (52) | 20 (37) | 51 (62) | |
| Missing | 12 (9) | 6 (11) | 6 (7) | |
| Albumin, <40 g/L | <.01 | |||
| Yes | 68 (50) | 36 (67) | 32 (39) | |
| No | 54 (40) | 15 (28) | 39 (48) | |
| Missing | 14 (10) | 3 (6) | 11 (13) | |
| WBC, ≥15 × 109 /L | .32 | |||
| Yes | 8 (6) | 5 (9) | 3 (4) | |
| No | 123 (90) | 46 (85) | 77 (94) | |
| Missing | 5 (4) | 3 (6) | 2 (2) | |
| Hb, <105 g/L | .68 | |||
| Yes | 17 (13) | 8 (15) | 9 (11) | |
| No | 104 (76) | 40 (74) | 64 (78) | |
| Missing | 15 (11) | 6 (11) | 9 (11) | |
| Lymph, <0.6 × 109/L | .74 | |||
| Yes | 7 (4) | 2 (4) | 5 (6) | |
| No | 113 (89) | 48 (89) | 65 (79) | |
| Missing | 16 (7) | 4 (7) | 12 (15) | |
| Histological subtype | .21 | |||
| NS | 97 (71) | 34 (63) | 63 (77) | |
| MC | 24 (18) | 13 (24) | 11 (13) | |
| LC/ UC | 15 (11) | 7 (13) | 8 (10) | |
| Items . | Entire cohort (N = 136), no. (%) . | IL-6+ leukocytes, no. (%) . | P . | |
|---|---|---|---|---|
| ≥1% (n = 54) . | <1% (n = 82) . | |||
| Age, y | .02 | |||
| ≥45 | 40 (29) | 22 (41) | 18 (22) | |
| <45 | 96 (71) | 32 (59) | 64 (78) | |
| Missing | 0 (0) | 0 (0) | 0 (0) | |
| Sex | .98 | |||
| Male | 81 (60) | 32 (60) | 49 (60) | |
| Female | 55 (40) | 22 (40) | 33 (40) | |
| Missing | 0 (0) | 0 (0) | 0 (0) | |
| Stage | .07 | |||
| IA-IIA | 57 (42) | 17 (31) | 40 (49) | |
| IIB-IVB | 77 (57) | 36 (67) | 41 (50) | |
| Missing | 2 (1) | 1 (2) | 1 (1) | |
| B symptoms | .01 | |||
| Yes | 62 (46) | 32 (59) | 30 (37) | |
| No | 72 (53) | 21 (39) | 51 (62) | |
| Missing | 2 (1) | 1 (2) | 1 (1) | |
| IPS | .05 | |||
| >2 | 24 (18) | 15 (28) | 9 (11) | |
| <2 | 78 (57) | 29 (54) | 49 (60) | |
| Missing | 34 (25) | 10 (18) | 24 (29) | |
| EBV | .25 | |||
| Yes | 32 (24) | 16 (30) | 16 (20) | |
| No | 101 (74) | 37 (69) | 64 (78) | |
| Missing | 3 (2) | 1 (1) | 2 (2) | |
| ESR, ≥50 mm/h | <.01 | |||
| Yes | 53 (39) | 28 (52) | 25 (30) | |
| No | 71 (52) | 20 (37) | 51 (62) | |
| Missing | 12 (9) | 6 (11) | 6 (7) | |
| Albumin, <40 g/L | <.01 | |||
| Yes | 68 (50) | 36 (67) | 32 (39) | |
| No | 54 (40) | 15 (28) | 39 (48) | |
| Missing | 14 (10) | 3 (6) | 11 (13) | |
| WBC, ≥15 × 109 /L | .32 | |||
| Yes | 8 (6) | 5 (9) | 3 (4) | |
| No | 123 (90) | 46 (85) | 77 (94) | |
| Missing | 5 (4) | 3 (6) | 2 (2) | |
| Hb, <105 g/L | .68 | |||
| Yes | 17 (13) | 8 (15) | 9 (11) | |
| No | 104 (76) | 40 (74) | 64 (78) | |
| Missing | 15 (11) | 6 (11) | 9 (11) | |
| Lymph, <0.6 × 109/L | .74 | |||
| Yes | 7 (4) | 2 (4) | 5 (6) | |
| No | 113 (89) | 48 (89) | 65 (79) | |
| Missing | 16 (7) | 4 (7) | 12 (15) | |
| Histological subtype | .21 | |||
| NS | 97 (71) | 34 (63) | 63 (77) | |
| MC | 24 (18) | 13 (24) | 11 (13) | |
| LC/ UC | 15 (11) | 7 (13) | 8 (10) | |
Test of independence was analyzed with the χ2 test or Fisher exact test.
EBV, Epstein-Barr virus; ESR, erythrocyte sedimentation rate; Hb, hemoglobin; IPS, International Prognostic Index; LC/UC, lymphocyte rich/depleted or unclassifiable; Lymph, peripheral lymphocyte count; MC, mixed cellularity; NS, nodular sclerosis; WBC, white blood count.