Median time to neutrophil and platelet recovery from treatment initiation of the last induction in patients who achieved CR or CRi
| . | 1 induction cycle . | 2 induction cycles . | ||
|---|---|---|---|---|
| CPX-351 . | 7+3 . | CPX-351 . | 7+3 . | |
| CR+CRi, n | 58 | 34 | 15 | 18 |
| Median (IQR) time to ANC recovery ≥0.5 × 103 neutrophils/μL, d | 35 (29, 41) | 29 (28, 35) | 35 (28, 44) | 28 (22, 29) |
| Median (IQR) time to platelet recovery ≥50 × 103 platelets/μL, d | 36.5 (29, 43)* | 29 (27, 36)* | 35 (28, 48)† | 24 (21, 29)† |
| CR, n | 47 | 28 | 10 | 12 |
| Median (IQR) time to ANC recovery ≥1 × 103 neutrophils/μL, d | 37 (30, 42) | 29 (28, 35) | 34.5 (28, 42) | 28 (24, 29.5) |
| Median (IQR) time to platelet recovery ≥100 × 103 platelets/μL, d | 40 (34, 47) | 30 (28, 35.5) | 35.5 (33, 42) | 28.5 (22, 33.5) |
| . | 1 induction cycle . | 2 induction cycles . | ||
|---|---|---|---|---|
| CPX-351 . | 7+3 . | CPX-351 . | 7+3 . | |
| CR+CRi, n | 58 | 34 | 15 | 18 |
| Median (IQR) time to ANC recovery ≥0.5 × 103 neutrophils/μL, d | 35 (29, 41) | 29 (28, 35) | 35 (28, 44) | 28 (22, 29) |
| Median (IQR) time to platelet recovery ≥50 × 103 platelets/μL, d | 36.5 (29, 43)* | 29 (27, 36)* | 35 (28, 48)† | 24 (21, 29)† |
| CR, n | 47 | 28 | 10 | 12 |
| Median (IQR) time to ANC recovery ≥1 × 103 neutrophils/μL, d | 37 (30, 42) | 29 (28, 35) | 34.5 (28, 42) | 28 (24, 29.5) |
| Median (IQR) time to platelet recovery ≥100 × 103 platelets/μL, d | 40 (34, 47) | 30 (28, 35.5) | 35.5 (33, 42) | 28.5 (22, 33.5) |
ANC, absolute neutrophil count; IQR, interquartile range.
Platelet recovery for patients achieving CR or CRi in 1 induction cycle was available for 56 patients in the CPX-351 arm and 32 patients in the 7+3 arm.
Platelet recovery for patients achieving CR or CRi in 2 induction cycles was available for 14 patients in the CPX-351 arm and 17 patients in the 7+3 arm.