Table 1.

InO dose escalation and de-escalation schedule

Dose levelIV InO dose (mg/m2)
Course 1Courses 2-6*
Day 1Day 8Day 15Total doses per courseDay 1Day 8†Day 15†Total doses per course
–2 0.4 0.2 0.2 0.8 0.2 0.2 0.2 0.6 
–1 0.5 0.3 0.3 1.1 0.3 0.3 0.3 0.9 
+1 (start) 0.6 0.4 0.4 1.4 0.4 0.4 0.4 1.2 
+2 0.8 0.5 0.5 1.8 0.5 0.5 0.5 1.5 
+3 1.0 0.6 0.6 2.2 0.6 0.6 0.6 1.8 
Dose levelIV InO dose (mg/m2)
Course 1Courses 2-6*
Day 1Day 8Day 15Total doses per courseDay 1Day 8†Day 15†Total doses per course
–2 0.4 0.2 0.2 0.8 0.2 0.2 0.2 0.6 
–1 0.5 0.3 0.3 1.1 0.3 0.3 0.3 0.9 
+1 (start) 0.6 0.4 0.4 1.4 0.4 0.4 0.4 1.2 
+2 0.8 0.5 0.5 1.8 0.5 0.5 0.5 1.5 
+3 1.0 0.6 0.6 2.2 0.6 0.6 0.6 1.8 
*

After course 1, in patients who have achieved a CR, the day 1 dose is decreased slightly because of no loading dose requirement. In patients who have not yet achieved a CR after course 1, a loading dose similar to that in course 1 was given in course 2, but not in subsequent courses.

†

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