Baseline characteristics
| Patient characteristics . | Patients with hemophilia B (N = 454) . | Controls (N = 454) . | P* . |
|---|---|---|---|
| Demographics | |||
| Age, mean (SD), y | 46.0 (18.4) | 46.0 (18.4) | 1.000 |
| Geographic region, n (%) | 1.000 | ||
| North central | 132 (29.1) | 132 (29.1) | |
| Northeast | 90 (19.8) | 90 (19.8) | |
| South | 163 (35.9) | 163 (35.9) | |
| West | 69 (15.2) | 69 (15.2) | |
| Insurance type, n (%) | 1.000 | ||
| Comprehensive | 33 (7.3) | 33 (7.3) | |
| Preferred provider organization | 276 (60.8) | 276 (60.8) | |
| Capitated | 50 (11.0) | 50 (11.0) | |
| Other | 95 (20.9) | 95 (20.9) | |
| Index year, n (%) | 1.000 | ||
| 2012-2013 | 184 (40.5) | 184 (40.5) | |
| 2014-2015 | 131 (28.9) | 131 (28.9) | |
| 2016-2018 | 139 (30.6) | 139 (30.6) | |
| Comorbidities | |||
| Charlson Comorbidity Index, mean (SD) | 0.9 (1.7) | 0.3 (0.9) | <.001† |
| Hemophilia-related comorbidities, n (%) | |||
| HIV/AIDS | 17 (3.7) | 1 (0.2) | <.001† |
| Hepatitis B | 7 (1.5) | 0 (0.0) | .008† |
| Hepatitis C | 76 (16.7) | 2 (0.4) | <.001† |
| Prescription medication use, n (%) | |||
| Pain medication | 201 (44.3) | 130 (28.6) | <.001† |
| Antidepressant or antianxiety | 78 (17.2) | 50 (11.0) | .008† |
| Number of bleeding events, mean (SD) | |||
| Hemarthrosis | 0.10 (0.77) | 0.002 (0.05) | <.001† |
| Hemorrhages | 0.23 (0.84) | 0.03 (0.26) | <.001† |
| Joint effusions | 0.08 (0.54) | 0.02 (0.21) | .002† |
| Contusions | 0.11 (0.41) | 0.03 (0.19) | <.001† |
| Joint-related problems, n (%) | |||
| Joint pain | 111 (24.4) | 54 (11.9) | <.001† |
| Stiff joints | 11 (2.4) | 0 (0.0) | <.001† |
| Difficulty walking | 5 (1.1) | 1 (0.2) | .102 |
| Osteoarthritis | 67 (14.8) | 30 (6.6) | <.001† |
| Arthropathy | 17 (3.7) | 0 (0.0) | <.001† |
| Patient characteristics . | Patients with hemophilia B (N = 454) . | Controls (N = 454) . | P* . |
|---|---|---|---|
| Demographics | |||
| Age, mean (SD), y | 46.0 (18.4) | 46.0 (18.4) | 1.000 |
| Geographic region, n (%) | 1.000 | ||
| North central | 132 (29.1) | 132 (29.1) | |
| Northeast | 90 (19.8) | 90 (19.8) | |
| South | 163 (35.9) | 163 (35.9) | |
| West | 69 (15.2) | 69 (15.2) | |
| Insurance type, n (%) | 1.000 | ||
| Comprehensive | 33 (7.3) | 33 (7.3) | |
| Preferred provider organization | 276 (60.8) | 276 (60.8) | |
| Capitated | 50 (11.0) | 50 (11.0) | |
| Other | 95 (20.9) | 95 (20.9) | |
| Index year, n (%) | 1.000 | ||
| 2012-2013 | 184 (40.5) | 184 (40.5) | |
| 2014-2015 | 131 (28.9) | 131 (28.9) | |
| 2016-2018 | 139 (30.6) | 139 (30.6) | |
| Comorbidities | |||
| Charlson Comorbidity Index, mean (SD) | 0.9 (1.7) | 0.3 (0.9) | <.001† |
| Hemophilia-related comorbidities, n (%) | |||
| HIV/AIDS | 17 (3.7) | 1 (0.2) | <.001† |
| Hepatitis B | 7 (1.5) | 0 (0.0) | .008† |
| Hepatitis C | 76 (16.7) | 2 (0.4) | <.001† |
| Prescription medication use, n (%) | |||
| Pain medication | 201 (44.3) | 130 (28.6) | <.001† |
| Antidepressant or antianxiety | 78 (17.2) | 50 (11.0) | .008† |
| Number of bleeding events, mean (SD) | |||
| Hemarthrosis | 0.10 (0.77) | 0.002 (0.05) | <.001† |
| Hemorrhages | 0.23 (0.84) | 0.03 (0.26) | <.001† |
| Joint effusions | 0.08 (0.54) | 0.02 (0.21) | .002† |
| Contusions | 0.11 (0.41) | 0.03 (0.19) | <.001† |
| Joint-related problems, n (%) | |||
| Joint pain | 111 (24.4) | 54 (11.9) | <.001† |
| Stiff joints | 11 (2.4) | 0 (0.0) | <.001† |
| Difficulty walking | 5 (1.1) | 1 (0.2) | .102 |
| Osteoarthritis | 67 (14.8) | 30 (6.6) | <.001† |
| Arthropathy | 17 (3.7) | 0 (0.0) | <.001† |