Differential diagnoses of reticulocytopenic anemias
| Category . | Conditions . | Examples/associations . |
|---|---|---|
| Intrinsic bone marrow disorders | Acquired PRCA | LGL, thymoma, CVID, PB19, lymphoproliferative disorders, ABO-incompatible allo-SCT |
| Congenital PRCA | Diamond-Blackfan anemia | |
| Acquired AA | Idiopathic, postviral | |
| Congenital AA | Fanconi anemia | |
| Systemic | Acute/chronic infections | HIV, EBV |
| Nutritional | Iron, folic acid, vitamin B12 | |
| Metabolic | Hypothyroidism, chronic kidney failure | |
| Autoimmune disorders | Ulcerative colitis, Crohn disease, RA | |
| Drugs | Linezolid, chemotherapy | |
| Neoplastic | Hematologic malignancies | AML, MDS, myelofibrosis (spent phase of MPN) |
| Metastatic solid cancers | Prostate, breast cancer |
| Category . | Conditions . | Examples/associations . |
|---|---|---|
| Intrinsic bone marrow disorders | Acquired PRCA | LGL, thymoma, CVID, PB19, lymphoproliferative disorders, ABO-incompatible allo-SCT |
| Congenital PRCA | Diamond-Blackfan anemia | |
| Acquired AA | Idiopathic, postviral | |
| Congenital AA | Fanconi anemia | |
| Systemic | Acute/chronic infections | HIV, EBV |
| Nutritional | Iron, folic acid, vitamin B12 | |
| Metabolic | Hypothyroidism, chronic kidney failure | |
| Autoimmune disorders | Ulcerative colitis, Crohn disease, RA | |
| Drugs | Linezolid, chemotherapy | |
| Neoplastic | Hematologic malignancies | AML, MDS, myelofibrosis (spent phase of MPN) |
| Metastatic solid cancers | Prostate, breast cancer |
AML, acute myeloid leukemia; EBV, Epstein-Barr virus; MPN, myeloproliferative neoplasm; PB19, B19 parvovirus; RA, rheumatoid arthritis.