Table 1. Clinical characteristics and... | American Society of Hematology

Table 1.

Clinical characteristics and laboratory data of the family members

Participant	Sex	Age, y	Thrombotic events	Age at first VTE, y	PT/INR	aPTT, s*	FVIII:C, %†	FVIII:Ag, %‡	VWF:Ag, %§	Additional thrombophilic defects
Family A
II-3, proband	F	53‖	DVT and PE	31	2.88¶	26.5¶	422	432	165	No
I-4	F	77	DVT and PE	49	1.00	21.6	269	296	144	No
II-6	M	45	SVT and DVT	43	0.98	21.1	416	372	60	No
III-1	M	26	No	—	1.11	29.3	132	152	144	No
III-2	M	22	No	—	1.1	27.2	323	368	112	No
Family B
II-1, proband	M	41	DVT and PE	21	3.1¶	40¶	264	273	78	Heterozygous FV Leiden
I-2	F	66	DVT	24	0.93	22.2	508	457	68	Heterozygous FV Leiden
III-1	F	19	No	—	1.07	26.2	295	270	113	Heterozygous FV Leiden

Participant	Sex	Age, y	Thrombotic events	Age at first VTE, y	PT/INR	aPTT, s*	FVIII:C, %†	FVIII:Ag, %‡	VWF:Ag, %§	Additional thrombophilic defects
Family A
II-3, proband	F	53‖	DVT and PE	31	2.88¶	26.5¶	422	432	165	No
I-4	F	77	DVT and PE	49	1.00	21.6	269	296	144	No
II-6	M	45	SVT and DVT	43	0.98	21.1	416	372	60	No
III-1	M	26	No	—	1.11	29.3	132	152	144	No
III-2	M	22	No	—	1.1	27.2	323	368	112	No
Family B
II-1, proband	M	41	DVT and PE	21	3.1¶	40¶	264	273	78	Heterozygous FV Leiden
I-2	F	66	DVT	24	0.93	22.2	508	457	68	Heterozygous FV Leiden
III-1	F	19	No	—	1.07	26.2	295	270	113	Heterozygous FV Leiden

Participants are coded as in Figure 1.

INR, international normalized ratio; PT, prothrombin time; SVT, superficial vein thrombosis.

Normal range, 26 to 34 seconds.

Normal range, 58% to 162%.

Normal range, 64% to 156%.

Normal range, 52% to 178%.

Age at death.

Oral anticoagulant treatment (warfarin).