Haplotype association analysis of ABO SNPs with A GT activity in 213 VT patients from the MARTHA cohort
| ABO blood group . | rs2519093 . | rs8176719 . | rs579459 . | rs1053878 . | rs8176743 . | rs41302905 . | Haplotype frequencies . | Haplotype additive effects (95% CI) . |
|---|---|---|---|---|---|---|---|---|
| O1 | C | delG | T | G | C | C | 0.528 | Reference |
| O2 | C | G | C | G | C | T | 0.014 | β = −249.54 (−3115.8 to 2616.8); P = .864 |
| A1 | T | G | C | G | C | C | 0.357 | β = 7983.2 (7385.6-8580.8); P = 4.5 × 10−150 |
| A2 | C | G | T | A | C | C | 0.046 | β = 1655.6 (267.2-3044.0); P = .019 |
| B | C | G | T | G | T | C | 0.033 | β = −239.2 (−1475.0 to 996.6); P = .704 |
| ABO blood group . | rs2519093 . | rs8176719 . | rs579459 . | rs1053878 . | rs8176743 . | rs41302905 . | Haplotype frequencies . | Haplotype additive effects (95% CI) . |
|---|---|---|---|---|---|---|---|---|
| O1 | C | delG | T | G | C | C | 0.528 | Reference |
| O2 | C | G | C | G | C | T | 0.014 | β = −249.54 (−3115.8 to 2616.8); P = .864 |
| A1 | T | G | C | G | C | C | 0.357 | β = 7983.2 (7385.6-8580.8); P = 4.5 × 10−150 |
| A2 | C | G | T | A | C | C | 0.046 | β = 1655.6 (267.2-3044.0); P = .019 |
| B | C | G | T | G | T | C | 0.033 | β = −239.2 (−1475.0 to 996.6); P = .704 |
The analysis was conducted using THESIAS and adjusted for age, sex, and the first 4 principal components. Minor alleles are shown in bold.