Summary data for the association between ABO haplotypes and studied traits
| ABO blood group . | rs2519093 . | rs8176719 . | rs579459 . | rs1053878 . | rs8176743 . | rs41302905 . | Frequency* . | OR for VT† . | Impact on VWF/FVIII levels‡ . | Impact on ICAM1 levels‡ . |
|---|---|---|---|---|---|---|---|---|---|---|
| O1 | C | delG | T | G | C | C | 0.63 | Reference | Reference | Reference |
| O2 | C | G | C | G | C | T | 0.02 | 0.70§ (0.57-0.86) | — | — |
| A1 | T | G | C | G | C | C | 0.20 | 1.78 (1.67-1.92) | ↑↑↑ | ↓↓↓ |
| A2 | C | G | T | A | C | C | 0.07 | 1.16 (1.03-1.31) | ↑ | ↓ |
| B | C | G | T | G | T | C | 0.08 | 1.76 (1.58-1.96) | ↑↑↑ | — |
| ABO blood group . | rs2519093 . | rs8176719 . | rs579459 . | rs1053878 . | rs8176743 . | rs41302905 . | Frequency* . | OR for VT† . | Impact on VWF/FVIII levels‡ . | Impact on ICAM1 levels‡ . |
|---|---|---|---|---|---|---|---|---|---|---|
| O1 | C | delG | T | G | C | C | 0.63 | Reference | Reference | Reference |
| O2 | C | G | C | G | C | T | 0.02 | 0.70§ (0.57-0.86) | — | — |
| A1 | T | G | C | G | C | C | 0.20 | 1.78 (1.67-1.92) | ↑↑↑ | ↓↓↓ |
| A2 | C | G | T | A | C | C | 0.07 | 1.16 (1.03-1.31) | ↑ | ↓ |
| B | C | G | T | G | T | C | 0.08 | 1.76 (1.58-1.96) | ↑↑↑ | — |
Minor alleles are shown in bold.
no effect of a given haplotype on the studied trait.
Haplotype frequencies in European ancestry populations.
Haplotypic risk estimate (95% CI) for VT obtained from the meta-analysis of results listed in supplemental Tables 1-6.
Direction (↑= increase; ↓= decrease) of haplotype effects on plasma levels. Strong vs modest effects are illustrated by 3 arrows vs 1 arrow.
This risk estimate exhibited statistical heterogeneity (P = 1.2 × 10−3) across the 6 investigated studies.