Reported non-ITD mutations within the FLT-3 JMD
| Mutation . | Reference . | Notes . |
|---|---|---|
| Deletion/indels | ||
| ΔG598_Y599 | Chatain et al14 | Differential autophosphorylation |
| F590_D593 delins | ||
| F590_V592 delins | Deeb et al15 | — |
| ΔF594_Y597 | ||
| ΔG598_Y599 | Shin et al16 | — |
| L576_V581 delins PR | ||
| D593Δ | Nguyen et al12 | Activating, resistance patterns similar to D835/I836 |
| Missense | ||
| Y572C | Fröhling et al22 | Activating |
| V592G | ||
| F594I | Gianfelici et al17 | — |
| F594L | Reindl et al18 | Potentially more sensitive than ITD; increased aneuploidy |
| V592A | ||
| V579A | ||
| F590GY591D | ||
| S574G | Syampurnawati et al19 | — |
| E598G | ||
| V579A | Stirewalt et al20 | — |
| V592A | ||
| F590GY591D | ||
| Truncation | ||
| Q569Vfs*2 | Sandhöfer et al21 | Dominant-negative effect on WT FLT-3 |
| Mutation . | Reference . | Notes . |
|---|---|---|
| Deletion/indels | ||
| ΔG598_Y599 | Chatain et al14 | Differential autophosphorylation |
| F590_D593 delins | ||
| F590_V592 delins | Deeb et al15 | — |
| ΔF594_Y597 | ||
| ΔG598_Y599 | Shin et al16 | — |
| L576_V581 delins PR | ||
| D593Δ | Nguyen et al12 | Activating, resistance patterns similar to D835/I836 |
| Missense | ||
| Y572C | Fröhling et al22 | Activating |
| V592G | ||
| F594I | Gianfelici et al17 | — |
| F594L | Reindl et al18 | Potentially more sensitive than ITD; increased aneuploidy |
| V592A | ||
| V579A | ||
| F590GY591D | ||
| S574G | Syampurnawati et al19 | — |
| E598G | ||
| V579A | Stirewalt et al20 | — |
| V592A | ||
| F590GY591D | ||
| Truncation | ||
| Q569Vfs*2 | Sandhöfer et al21 | Dominant-negative effect on WT FLT-3 |