In vivo hemostatic function of FVIII-QQ relative to FVIII-WT
| . | Tail clip, µg/kg . | FeCl3, µg/kg . | ||
|---|---|---|---|---|
| EC50 . | EC80 . | EC50 . | EC80 . | |
| FVIII-WT | 7.6 | 16.5 | 3.4 | 12.1 |
| FVIII-QQ | 1.1 | 2.0 | 1.2 | 1.5 |
| FVIII-QQ fold improvement | 6.9 | 8.3 | 2.8 | 8.1 |
| . | Tail clip, µg/kg . | FeCl3, µg/kg . | ||
|---|---|---|---|---|
| EC50 . | EC80 . | EC50 . | EC80 . | |
| FVIII-WT | 7.6 | 16.5 | 3.4 | 12.1 |
| FVIII-QQ | 1.1 | 2.0 | 1.2 | 1.5 |
| FVIII-QQ fold improvement | 6.9 | 8.3 | 2.8 | 8.1 |
EC50 or EC80 of FVIII dose required to normalize blood loss or time to vessel occlusion. FeCl3 indicates 7.5% ferric chloride injury model.