Correlation scores of signaling pathways inferred by PROGENy with Notch activity in root 1 vs root 2 leukemic cells
| . | Correlation . | P . |
|---|---|---|
| PI3K – Notch | −0.69 | <2.2e−16 |
| VEGF – Notch | −0.12 | .022 |
| EGFR – Notch | −0.26 | 1.60e−06 |
| Hypoxia – Notch | 0.75 | <2.2e−16 |
| MAPK – Notch | 0.68 | <2.2e−16 |
| p53 – Notch | 0.7 | <2.2e−16 |
| TGFβ – Notch | 0.66 | <2.2e−16 |
| JAK/STAT – Notch | 0.52 | <2.2e−16 |
| TNFα – Notch | 0.62 | <2.2e−16 |
| NF-κB – Notch | 0.57 | <2.2e−16 |
| Trail – Notch | 0.54 | <2.2e−16 |
| PIM – Notch | 0.65 | <2.2e−16 |
| MYC – Notch | 0.74 | <2.2e−16 |
| . | Correlation . | P . |
|---|---|---|
| PI3K – Notch | −0.69 | <2.2e−16 |
| VEGF – Notch | −0.12 | .022 |
| EGFR – Notch | −0.26 | 1.60e−06 |
| Hypoxia – Notch | 0.75 | <2.2e−16 |
| MAPK – Notch | 0.68 | <2.2e−16 |
| p53 – Notch | 0.7 | <2.2e−16 |
| TGFβ – Notch | 0.66 | <2.2e−16 |
| JAK/STAT – Notch | 0.52 | <2.2e−16 |
| TNFα – Notch | 0.62 | <2.2e−16 |
| NF-κB – Notch | 0.57 | <2.2e−16 |
| Trail – Notch | 0.54 | <2.2e−16 |
| PIM – Notch | 0.65 | <2.2e−16 |
| MYC – Notch | 0.74 | <2.2e−16 |
EGFR, endothelial growth factor receptor; MAPK, mitogen-activated protein kinase; TGF, transforming growth factor; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.