Table 3. Multivariate Cox model for... | American Society of Hematology

Table 3.

Multivariate Cox model for study cohorts undergoing HCT for MPN-BP vs de novo AML

	n	HR (95% CI)	P
aGVHD II-IV
De novo AML	4693	1.00 (Reference)	.32
MPN-BP	176	1.12 (0.90-1.40)
aGVHD III-IV
De novo AML	4677	1.00 (Reference)	.44
MPN-BP	174	1.14 (0.81-1.60)
cGVHD
De novo AML	4693	1.00 (Reference)	.47
MPN-BP	176	1.05 (0.93-1.18)
OS
In remission*
De novo AML	3511	1.00 (Reference)	.003
MPN-BP	101	1.40 (1.12 - 1.76)
Active leukemia†
De novo AML	1238	1.00 (Reference)	.59
MPN-BP	76	0.93 (0.72 - 1.20)
Relapse
In remission*
De novo AML	3461	1.00 (Reference)	<.0001
MPN-BP	101	2.18 (1.69-2.80)
Active leukemia†
De novo AML	1208	1.00 (Reference)	.30
MPN-BP	76	1.16 (0.88 - 1.54)
NRM
De novo AML	4669	1.00 (Reference)	.92
MPN-BP	177	1.02 (0.74-1.41)
PFS
De novo AML	4669	1.00 (Reference)	.0003
MPN-BP	177	1.35 (1.15-1.59)

	n	HR (95% CI)	P
aGVHD II-IV
De novo AML	4693	1.00 (Reference)	.32
MPN-BP	176	1.12 (0.90-1.40)
aGVHD III-IV
De novo AML	4677	1.00 (Reference)	.44
MPN-BP	174	1.14 (0.81-1.60)
cGVHD
De novo AML	4693	1.00 (Reference)	.47
MPN-BP	176	1.05 (0.93-1.18)
OS
In remission*
De novo AML	3511	1.00 (Reference)	.003
MPN-BP	101	1.40 (1.12 - 1.76)
Active leukemia†
De novo AML	1238	1.00 (Reference)	.59
MPN-BP	76	0.93 (0.72 - 1.20)
Relapse
In remission*
De novo AML	3461	1.00 (Reference)	<.0001
MPN-BP	101	2.18 (1.69-2.80)
Active leukemia†
De novo AML	1208	1.00 (Reference)	.30
MPN-BP	76	1.16 (0.88 - 1.54)
NRM
De novo AML	4669	1.00 (Reference)	.92
MPN-BP	177	1.02 (0.74-1.41)
PFS
De novo AML	4669	1.00 (Reference)	.0003
MPN-BP	177	1.35 (1.15-1.59)

CI, confidence interval; HR, hazard ratio.

In remission: CR1/CR2 for de novo AML and blasts <5% in peripheral blood and bone marrow for MPN-BP and post-MDS AML.

Active leukemia: blasts in peripheral blood or bone marrow <5%.