Table 5. Multivariate Cox proportional... | American Society of Hematology

Table 5.

Multivariate Cox proportional hazards regression analyses focusing on the status of MRD detected at first and second time points

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.996	0.985	1.008	.535	0.998	0.987	1.008	.654	1.011	0.999	1.023	.074
WBC counts*	1.004	1.001	1.007	.004	1.003	1.001	1.006	.010	1.003	1.000	1.006	.039
ELN riskstratification
Intermediate vs favorable	2.047	1.357	3.086	.001	2.065	1.407	3.030	<.001	2.475	1.596	3.837	<.001
Adverse vs favorable	2.419	1.510	3.875	<.001	2.455	1.586	3.799	<.001	2.722	1.678	4.416	<.001
Number of induction chemotherapy cycles†	1.502	0.990	2.278	.056	1.490	1.017	2.185	.041	1.476	0.984	2.213	.060
HSCT at CR1‡	0.196	0.112	0.344	<.001	0.280	0.175	0.448	<.001	0.562	0.350	0.902	.017
MRD status§
MRD^1st+MRD^2nd−	1.544	0.981	2.431	.061	1.393	0.911	2.129	.126	1.355	0.871	2.183	.212
MRD^1st−MRD^2nd+	4.018	1.868	8.642	<.001	3.373	1.584	7.185	.002	1.777	0.697	4.529	.228
MRD^1st+MRD^2nd+	2.354	1.536	3.606	<.001	2.259	1.527	3.343	<.001	1.828	1.189	2.811	.006

Variables	CIR				RFS				OS
Variables	HR	Lower	Upper	P	HR	Lower	Upper	P	HR	Lower	Upper	P
Age*	0.996	0.985	1.008	.535	0.998	0.987	1.008	.654	1.011	0.999	1.023	.074
WBC counts*	1.004	1.001	1.007	.004	1.003	1.001	1.006	.010	1.003	1.000	1.006	.039
ELN riskstratification
Intermediate vs favorable	2.047	1.357	3.086	.001	2.065	1.407	3.030	<.001	2.475	1.596	3.837	<.001
Adverse vs favorable	2.419	1.510	3.875	<.001	2.455	1.586	3.799	<.001	2.722	1.678	4.416	<.001
Number of induction chemotherapy cycles†	1.502	0.990	2.278	.056	1.490	1.017	2.185	.041	1.476	0.984	2.213	.060
HSCT at CR1‡	0.196	0.112	0.344	<.001	0.280	0.175	0.448	<.001	0.562	0.350	0.902	.017
MRD status§
MRD^1st+MRD^2nd−	1.544	0.981	2.431	.061	1.393	0.911	2.129	.126	1.355	0.871	2.183	.212
MRD^1st−MRD^2nd+	4.018	1.868	8.642	<.001	3.373	1.584	7.185	.002	1.777	0.697	4.529	.228
MRD^1st+MRD^2nd+	2.354	1.536	3.606	<.001	2.259	1.527	3.343	<.001	1.828	1.189	2.811	.006

Continuous variables.

Two cycles vs 1 cycle.

HSCT at CR1 vs HSCT at other disease status or without HSCT.

§Reference is MRD^1st−MRD^2nd−.