Details of interaction interfaces between FVIII and VWF
| Interface . | Surface area (Å2) . | No. of hydrogen bonds/salt bridges . | |
|---|---|---|---|
| Global interactions | |||
| FVIII | VWF-D′D3 | 2486 | 22/12 |
| FVIII | VWF-D′ | 1817 | 19/9 |
| FVIII | VWF-D3 | 669 | 3/3 |
| Detailed interactions | |||
| FVIII C1 | VWF-D′ | 943 | 7/2 |
| FVIII-a3 peptide | VWF-D′ | 480 | 11/7 |
| C2 | VWF-D3 | 472 | 2/2 |
| A3 | VWF-D′ | 394 | 1/0 |
| C1 | VWF-D3 | 197 | 1/1 |
| FVIII-a3 peptide | FVIII-A3* | 84 | 0/0 |
| FVIII-a3 peptide | FIII-C1* | 81 | 3/0 |
| Interface . | Surface area (Å2) . | No. of hydrogen bonds/salt bridges . | |
|---|---|---|---|
| Global interactions | |||
| FVIII | VWF-D′D3 | 2486 | 22/12 |
| FVIII | VWF-D′ | 1817 | 19/9 |
| FVIII | VWF-D3 | 669 | 3/3 |
| Detailed interactions | |||
| FVIII C1 | VWF-D′ | 943 | 7/2 |
| FVIII-a3 peptide | VWF-D′ | 480 | 11/7 |
| C2 | VWF-D3 | 472 | 2/2 |
| A3 | VWF-D′ | 394 | 1/0 |
| C1 | VWF-D3 | 197 | 1/1 |
| FVIII-a3 peptide | FVIII-A3* | 84 | 0/0 |
| FVIII-a3 peptide | FIII-C1* | 81 | 3/0 |
FVIII-FVIII interaction.