Grade ≥3 nonhematologic adverse events
| Adverse event . | Arm A: G3139 (n = 247) . | Arm B: control (n = 244) . | Total (n = 491) . | P* . |
|---|---|---|---|---|
| Febrile neutropenia | 181 (73) | 187 (77) | 368 (75) | .41 |
| Infection | 138 (56) | 138 (57) | 276 (56) | .93 |
| Hypokalemia | 57 (23) | 50 (20) | 107 (22) | .51 |
| Dyspnea | 40 (16) | 51 (21) | 91 (19) | .20 |
| Hypoxia | 43 (17) | 43 (18) | 86 (18) | 1.00 |
| Hypophosphatemia | 41 (17) | 38 (16) | 79 (16) | .81 |
| Hyperglycemia | 33 (13) | 42 (17) | 75 (15) | .26 |
| Fatigue | 32 (13) | 37 (15) | 69 (14) | .52 |
| Hypocalcemia | 32 (13) | 33 (14) | 65 (13) | .89 |
| Hypotension | 28 (11) | 36 (15) | 64 (13) | .29 |
| Hyponatremia | 33 (13) | 30 (12) | 63 (13) | .79 |
| Diarrhea | 28 (11) | 32 (13) | 60 (12) | .58 |
| Hypoalbuminemia | 39 (16) | 17 (7) | 56 (11) | .002 |
| Pain | 22 (9) | 34 (14) | 56 (11) | .09 |
| Hyperbilirubinemia | 23 (9) | 32 (13) | 55 (11) | .20 |
| Rash/desquamation | 24 (10) | 28 (11) | 52 (11) | .56 |
| Anorexia | 21 (9) | 27 (11) | 48 (10) | .36 |
| Infection (other) | 23 (9) | 22 (9) | 45 (9) | 1.00 |
| Renal failure | 29 (12) | 14 (6) | 43 (9) | .03 |
| Pneumonitis/pulmonary infiltrates | 19 (8) | 21 (9) | 40 (8) | .74 |
| Adverse event . | Arm A: G3139 (n = 247) . | Arm B: control (n = 244) . | Total (n = 491) . | P* . |
|---|---|---|---|---|
| Febrile neutropenia | 181 (73) | 187 (77) | 368 (75) | .41 |
| Infection | 138 (56) | 138 (57) | 276 (56) | .93 |
| Hypokalemia | 57 (23) | 50 (20) | 107 (22) | .51 |
| Dyspnea | 40 (16) | 51 (21) | 91 (19) | .20 |
| Hypoxia | 43 (17) | 43 (18) | 86 (18) | 1.00 |
| Hypophosphatemia | 41 (17) | 38 (16) | 79 (16) | .81 |
| Hyperglycemia | 33 (13) | 42 (17) | 75 (15) | .26 |
| Fatigue | 32 (13) | 37 (15) | 69 (14) | .52 |
| Hypocalcemia | 32 (13) | 33 (14) | 65 (13) | .89 |
| Hypotension | 28 (11) | 36 (15) | 64 (13) | .29 |
| Hyponatremia | 33 (13) | 30 (12) | 63 (13) | .79 |
| Diarrhea | 28 (11) | 32 (13) | 60 (12) | .58 |
| Hypoalbuminemia | 39 (16) | 17 (7) | 56 (11) | .002 |
| Pain | 22 (9) | 34 (14) | 56 (11) | .09 |
| Hyperbilirubinemia | 23 (9) | 32 (13) | 55 (11) | .20 |
| Rash/desquamation | 24 (10) | 28 (11) | 52 (11) | .56 |
| Anorexia | 21 (9) | 27 (11) | 48 (10) | .36 |
| Infection (other) | 23 (9) | 22 (9) | 45 (9) | 1.00 |
| Renal failure | 29 (12) | 14 (6) | 43 (9) | .03 |
| Pneumonitis/pulmonary infiltrates | 19 (8) | 21 (9) | 40 (8) | .74 |
Data are given as n (%).
Two-sided P values from Fisher’s exact test.