Response to KTE-X19
| Response category . | Dose level . | Total (N = 45) . | ||
|---|---|---|---|---|
| 2 × 106 (n = 6) . | 1 × 106 (n = 23) . | 0.5 × 106 (n = 16) . | ||
| CR | 4 (67) | 19 (83) | 8 (50) | 31 (69) |
| CR | 3 (50) | 15 (65) | 6 (38) | 24 (53) |
| CRi | 1 (17) | 4 (17) | 2 (13) | 7 (16) |
| BFBM | 0 | 1 (4) | 1 (6) | 2 (4) |
| Partial remission | 0 | 1 (4)* | 0 | 1 (2) |
| No response | 1 (17) | 2 (9) | 6 (38) | 9 (20) |
| Unknown or not evaluable | 1 (17)† | 0 | 1 (6)‡ | 2 (4) |
| Response category . | Dose level . | Total (N = 45) . | ||
|---|---|---|---|---|
| 2 × 106 (n = 6) . | 1 × 106 (n = 23) . | 0.5 × 106 (n = 16) . | ||
| CR | 4 (67) | 19 (83) | 8 (50) | 31 (69) |
| CR | 3 (50) | 15 (65) | 6 (38) | 24 (53) |
| CRi | 1 (17) | 4 (17) | 2 (13) | 7 (16) |
| BFBM | 0 | 1 (4) | 1 (6) | 2 (4) |
| Partial remission | 0 | 1 (4)* | 0 | 1 (2) |
| No response | 1 (17) | 2 (9) | 6 (38) | 9 (20) |
| Unknown or not evaluable | 1 (17)† | 0 | 1 (6)‡ | 2 (4) |
Data are presented as n (%).
Patient had extramedullary disease at response assessment. Of the 3 other patients with extramedullary disease, 2 achieved a CR, and 1 had stable disease (no response); all had extramedullary disease present at response assessment.
Patient died on day 6 as a result of multiorgan failure secondary to CRS.
Patient died on day 7 as a result of cerebrovascular accident (stroke) in the context of CRS and neurologic events.