Evaluation of the independent effects of EASIX, ferritin, and CRP levels on ICANS grades 2 to 4
| . | Parameters . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Risk groups . | Ferritin . | EASIX/CRP . | n* . | Events, n . | CumInc, % (range) . | HR . | 95% CI . | P . |
| High risk | High | Any level | 35 | 26 | 74 | 3.6 | 1.9-6.9 | <.001 |
| Intermediate risk | Low | High EASIX or | 41 | 21 | 51 (38-69) | 2.1 | 1.1-3.9 | .025 |
| High CRP | 19 | 10 | 53 (34-81) | |||||
| Low risk | Low | Low EASIX, and low CRP | 45 | 13 | 29 (18-46) | 1.0 | — | — |
| . | Parameters . | . | . | . | . | . | . | |
|---|---|---|---|---|---|---|---|---|
| Risk groups . | Ferritin . | EASIX/CRP . | n* . | Events, n . | CumInc, % (range) . | HR . | 95% CI . | P . |
| High risk | High | Any level | 35 | 26 | 74 | 3.6 | 1.9-6.9 | <.001 |
| Intermediate risk | Low | High EASIX or | 41 | 21 | 51 (38-69) | 2.1 | 1.1-3.9 | .025 |
| High CRP | 19 | 10 | 53 (34-81) | |||||
| Low risk | Low | Low EASIX, and low CRP | 45 | 13 | 29 (18-46) | 1.0 | — | — |
High ferritin, levels in the upper quartile (ferritin >1583 ng/mL); high EASIX, levels above the median (>2.1); high CRP, levels above the median (>21 mg\L).
High- vs intermediate-risk groups: HR, 1.8; 95% CI 1.1-2.9; P = 0.03; high EASIX vs high CRP within intermediate-risk groups: HR, 0.9; 95% CI, 0.4-1.9, P = 0.8.
CumInc, cumulative incidence; HR, hazard ratio; CI, confidence interval.
*Only patients with available ferritin levels were eligible for this analysis.