Cox proportional hazard model to estimate hazard ratios and 95% CI for time to first therapy and OS in MBL and Rai 0 CLL
| CLL-IPI risk group . | MBL . | |||||
|---|---|---|---|---|---|---|
| Time to first therapy . | Overall survival . | |||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Intermediate vs low | 2.7 | 1.6-4.5 | .0002 | 1.9 | 1.1-3.1 | .01 |
| High vs low | 6.2 | 3.1-12.5 | <.0001 | 2.6 | 1.4-5.1 | .003 |
| Very high vs low | Not estimable | — | — | 5.3 | 1.3-22.0 | .02 |
| CLL-IPI risk group | CLL | |||||
| Time to first therapy | Overall survival | |||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Intermediate vs low | 2.9 | 2.1-4.0 | <.0001 | 2.0 | 1.4-3.0 | .0005 |
| High vs low | 6.1 | 3.7-9.5 | <.0001 | 4.2 | 2.5-7.2 | <.0001 |
| Very high vs low | 5.4 | 1.8-15.0 | .002 | 12.2 | 5.9-25.1 | <.001 |
| CLL-IPI risk group . | MBL . | |||||
|---|---|---|---|---|---|---|
| Time to first therapy . | Overall survival . | |||||
| HR . | 95% CI . | P . | HR . | 95% CI . | P . | |
| Intermediate vs low | 2.7 | 1.6-4.5 | .0002 | 1.9 | 1.1-3.1 | .01 |
| High vs low | 6.2 | 3.1-12.5 | <.0001 | 2.6 | 1.4-5.1 | .003 |
| Very high vs low | Not estimable | — | — | 5.3 | 1.3-22.0 | .02 |
| CLL-IPI risk group | CLL | |||||
| Time to first therapy | Overall survival | |||||
| HR | 95% CI | P | HR | 95% CI | P | |
| Intermediate vs low | 2.9 | 2.1-4.0 | <.0001 | 2.0 | 1.4-3.0 | .0005 |
| High vs low | 6.1 | 3.7-9.5 | <.0001 | 4.2 | 2.5-7.2 | <.0001 |
| Very high vs low | 5.4 | 1.8-15.0 | .002 | 12.2 | 5.9-25.1 | <.001 |
Values in bold indicate P < .05.