Recurrent CNAs and CN-LOHs in T-LLy with the incidence in ETP and non-ETP cases along with the genomic coordinates
| Chromosome . | Cases . | Incidence in ETP-LLy . | Incidence in Non-ETP T-LLy . | P value (ETP vs non ETP) . | Minimal common region . | Start genomic coordinates . | Stop genomic coordinates . | Affected genes . |
|---|---|---|---|---|---|---|---|---|
| Recurrent gains | ||||||||
| 6 | 5, 15 | 0/9 | 2/15 | .511 | 6q23.3 | 135c483,742 | 135c754,471 | MYB |
| 9 | 11, 23 | 1/9 | 1/15 | 1.000 | 9q34.12q34.13 | 133c719,421 | 134c094,802 | NUP14-ABL1 |
| Recurrent losses | ||||||||
| 1 | 19, 22, 23, 24 | 4/9 | 0/15 | .012* | 1p36.32p36.31 | 3c921c449 | 7c050c061 | RPL11 |
| 12 | 19, 20, 22 | 3/9 | 0/15 | .042* | 12p12.3 | 17c200,436 | 18c268,880 | RERGL |
| 13 | 6, 11 | 0/9 | 2/15 | .511 | 13q14.2 | 48c984,722 | 49c065,037 | RB1 |
| 4 | 14, 15 | 0/9 | 2/15 | .511 | 4q12 | 54c324,930 | 55c102,425 | FIP1L1, CHIC, PDGFRa |
| X | 11, 23 | 1/9 | 1/15 | 1.000 | Xq26.2q26.3 | 130c973,820 | 134c242,874 | PHF6 |
| Recurrent LOHs | ||||||||
| 4 | 8, 15 | 0/9 | 2/15 | .511 | 4q28.1q35.2 | 126c144,980 | 191c154,276 | FBXW7 |
| Recurrent losses and/or LOHs | ||||||||
| 9 | 1-11, 13-15, 17, 21, 22, 24 | 4/9 | 14/15 | .015* | 9p21.3 | 21c901,263 | 21c993,468 | CDKN2A, CDKN2B |
| Chromosome . | Cases . | Incidence in ETP-LLy . | Incidence in Non-ETP T-LLy . | P value (ETP vs non ETP) . | Minimal common region . | Start genomic coordinates . | Stop genomic coordinates . | Affected genes . |
|---|---|---|---|---|---|---|---|---|
| Recurrent gains | ||||||||
| 6 | 5, 15 | 0/9 | 2/15 | .511 | 6q23.3 | 135c483,742 | 135c754,471 | MYB |
| 9 | 11, 23 | 1/9 | 1/15 | 1.000 | 9q34.12q34.13 | 133c719,421 | 134c094,802 | NUP14-ABL1 |
| Recurrent losses | ||||||||
| 1 | 19, 22, 23, 24 | 4/9 | 0/15 | .012* | 1p36.32p36.31 | 3c921c449 | 7c050c061 | RPL11 |
| 12 | 19, 20, 22 | 3/9 | 0/15 | .042* | 12p12.3 | 17c200,436 | 18c268,880 | RERGL |
| 13 | 6, 11 | 0/9 | 2/15 | .511 | 13q14.2 | 48c984,722 | 49c065,037 | RB1 |
| 4 | 14, 15 | 0/9 | 2/15 | .511 | 4q12 | 54c324,930 | 55c102,425 | FIP1L1, CHIC, PDGFRa |
| X | 11, 23 | 1/9 | 1/15 | 1.000 | Xq26.2q26.3 | 130c973,820 | 134c242,874 | PHF6 |
| Recurrent LOHs | ||||||||
| 4 | 8, 15 | 0/9 | 2/15 | .511 | 4q28.1q35.2 | 126c144,980 | 191c154,276 | FBXW7 |
| Recurrent losses and/or LOHs | ||||||||
| 9 | 1-11, 13-15, 17, 21, 22, 24 | 4/9 | 14/15 | .015* | 9p21.3 | 21c901,263 | 21c993,468 | CDKN2A, CDKN2B |
Cases 1-15 are non-ETP T-LLy, and cases 16-24 are ETP-LLy.
P < .05.