Summary of recommendations for secondary prevention of VTE according to the risk of recurrence without indefinite treatment
| Patients with: . | Estimated risk of recurrence (patient-years) . | Proposed treatment . | Specific strategy . |
|---|---|---|---|
| A recurrent unprovoked DVT or PE | DVT: 6.6 per 100 PE: 5.4 per 100 Total VTE: 12 per 100 | After completing an initial treatment of 3 to 6 months, use indefinite anticoagulation (strong Recommendations 10 and 11). | Use anticoagulants instead of aspirin (conditional Recommendation 13). Use DOACs at standard doses rather than lower doses of DOACs or VKAs (conditional Recommendations 3 and 14). If DOACs are not affordable, VKAs remains a good alternative (conditional Recommendation 3). |
| A provoked DVT or PE related to a chronic risk factor | DVT: 5.3 per 100 PE: 4.4 per 100 Total VTE: 9.7 per 100 | ||
| An unprovoked DVT or PE | DVT: 4.1 per 100 PE: 3.3 per 100 Total VTE: 7.4 per 100 | After completing an initial treatment of 3 to 6 months, offer indefinite anticoagulation (conditional Recommendations 9 and 12). | |
| Recurrent provoked DVT or PE | DVT: 3.1 per 100 PE: 2.5 per 100 Total VTE: 5.6 per 100 |
| Patients with: . | Estimated risk of recurrence (patient-years) . | Proposed treatment . | Specific strategy . |
|---|---|---|---|
| A recurrent unprovoked DVT or PE | DVT: 6.6 per 100 PE: 5.4 per 100 Total VTE: 12 per 100 | After completing an initial treatment of 3 to 6 months, use indefinite anticoagulation (strong Recommendations 10 and 11). | Use anticoagulants instead of aspirin (conditional Recommendation 13). Use DOACs at standard doses rather than lower doses of DOACs or VKAs (conditional Recommendations 3 and 14). If DOACs are not affordable, VKAs remains a good alternative (conditional Recommendation 3). |
| A provoked DVT or PE related to a chronic risk factor | DVT: 5.3 per 100 PE: 4.4 per 100 Total VTE: 9.7 per 100 | ||
| An unprovoked DVT or PE | DVT: 4.1 per 100 PE: 3.3 per 100 Total VTE: 7.4 per 100 | After completing an initial treatment of 3 to 6 months, offer indefinite anticoagulation (conditional Recommendations 9 and 12). | |
| Recurrent provoked DVT or PE | DVT: 3.1 per 100 PE: 2.5 per 100 Total VTE: 5.6 per 100 |