Multivariate Cox models for OS in patients according to cytogenetic risk
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| Non–poor risk cytogenetics (n = 387) | |||
| NPM1 mutation | 0.57 | 0.41-0.77 | .0004 |
| FLT3-ITD low ratio | 1.85 | 1.31-2.62 | .0005 |
| FLT3-ITD high ratio | 3.51 | 2.03-6.08 | <.0001 |
| NRAS mutation | 1.54 | 1.07-2.20 | .019 |
| ASXL1 mutation | 1.89 | 1.34-2.67 | .0003 |
| DNMT3A mutation | 1.86 | 1.40-2.47 | <.0001 |
| Poor risk cytogenetics (n = 84) | |||
| KRAS mutation | 3.60 | 1.68-7.72 | .001 |
| TP53 mutation | 2.49 | 1.53-4.04 | .0003 |
| Variable . | HR . | 95% CI . | P . |
|---|---|---|---|
| Non–poor risk cytogenetics (n = 387) | |||
| NPM1 mutation | 0.57 | 0.41-0.77 | .0004 |
| FLT3-ITD low ratio | 1.85 | 1.31-2.62 | .0005 |
| FLT3-ITD high ratio | 3.51 | 2.03-6.08 | <.0001 |
| NRAS mutation | 1.54 | 1.07-2.20 | .019 |
| ASXL1 mutation | 1.89 | 1.34-2.67 | .0003 |
| DNMT3A mutation | 1.86 | 1.40-2.47 | <.0001 |
| Poor risk cytogenetics (n = 84) | |||
| KRAS mutation | 3.60 | 1.68-7.72 | .001 |
| TP53 mutation | 2.49 | 1.53-4.04 | .0003 |