Baseline characteristics of the Lifelines cohort and prevalence of cytopenias according to different proposed cutoff criteria.
| . | n . | Total cohort . | <60 y old . | ≥60 y old . |
|---|---|---|---|---|
| No. of individuals | 152180 | 152180 | 129728 | 22452 |
| Males | 152180 | 63130 (41.5) | 52886 (40.8) | 10244 (45.6) |
| Age, median (range), y | 152180 | 44 (18-93) | 42 (18-59) | 65 (60-93) |
| Hemoglobin level, mean (SD), g/dL | 147170 | 14.14 (1.27) | 14.12 (1.29) | 14.24 (1.16) |
| Platelet count, mean (SD), ×109/L | 147074 | 249.9 (56.6) | 251.7 (56.4) | 239.7 (56.8) |
| White blood cell count, mean (SD), ×109/L | 147171 | 6.10 (1.79) | 6.13 (1.73) | 5.92 (2.11) |
| Neutrophil count, mean (SD), ×109/L | 144676 | 3.33 (1.23) | 3.36 (1.25) | 3.15 (1.10) |
| Anemia (<12.0 g/dL [women] or <13.0 g/dL [men])* | 147170 | 6159 (4.2) | 5403 (4.2) | 756 (3.4) |
| Moderate (<11.0 g/dL)† | 147170 | 1272 (0.9) | 1186 (0.9) | 86 (0.4) |
| Severe (<10.0 g/dL)‡,§ | 147170 | 442 (0.3) | 419 (0.3) | 23 (0.1) |
| Thrombocytopenia (<150 × 109/L)* | 147074 | 2408 (1.6) | 1777 (1.4) | 631 (2.8) |
| Moderate (<100 × 109/L)†,§ | 147074 | 153 (0.1) | 117 (0.09) | 36 (0.2) |
| Neutropenia (<1.8 × 109/L)*,‡ | 144676 | 6925 (4.8) | 5643 (4.3) | 1282 (5.7) |
| Moderate (<1.5 × 109/L)† | 144676 | 2050 (1.4) | 1644 (1.3) | 406 (1.8) |
| Severe (<0.8 × 109/L)§ | 144676 | 30 (0.02) | 27 (0.02) | 3 (0.01) |
| . | n . | Total cohort . | <60 y old . | ≥60 y old . |
|---|---|---|---|---|
| No. of individuals | 152180 | 152180 | 129728 | 22452 |
| Males | 152180 | 63130 (41.5) | 52886 (40.8) | 10244 (45.6) |
| Age, median (range), y | 152180 | 44 (18-93) | 42 (18-59) | 65 (60-93) |
| Hemoglobin level, mean (SD), g/dL | 147170 | 14.14 (1.27) | 14.12 (1.29) | 14.24 (1.16) |
| Platelet count, mean (SD), ×109/L | 147074 | 249.9 (56.6) | 251.7 (56.4) | 239.7 (56.8) |
| White blood cell count, mean (SD), ×109/L | 147171 | 6.10 (1.79) | 6.13 (1.73) | 5.92 (2.11) |
| Neutrophil count, mean (SD), ×109/L | 144676 | 3.33 (1.23) | 3.36 (1.25) | 3.15 (1.10) |
| Anemia (<12.0 g/dL [women] or <13.0 g/dL [men])* | 147170 | 6159 (4.2) | 5403 (4.2) | 756 (3.4) |
| Moderate (<11.0 g/dL)† | 147170 | 1272 (0.9) | 1186 (0.9) | 86 (0.4) |
| Severe (<10.0 g/dL)‡,§ | 147170 | 442 (0.3) | 419 (0.3) | 23 (0.1) |
| Thrombocytopenia (<150 × 109/L)* | 147074 | 2408 (1.6) | 1777 (1.4) | 631 (2.8) |
| Moderate (<100 × 109/L)†,§ | 147074 | 153 (0.1) | 117 (0.09) | 36 (0.2) |
| Neutropenia (<1.8 × 109/L)*,‡ | 144676 | 6925 (4.8) | 5643 (4.3) | 1282 (5.7) |
| Moderate (<1.5 × 109/L)† | 144676 | 2050 (1.4) | 1644 (1.3) | 406 (1.8) |
| Severe (<0.8 × 109/L)§ | 144676 | 30 (0.02) | 27 (0.02) | 3 (0.01) |
Unless otherwise noted, data are n (%).
SD, standard deviation.
Generally accepted reference values, argued for by Greenberg et al to define cytopenias in MDSs11 and used to define ICUS in 2017.10
Used to define ICUS in 2007.13
WHO criteria to define cytopenias in MDS.14
Alternative criteria to define cytopenias relevant for prognosis in MDS (IPSS-R).12