Subdistribution hazard ratios for death from hematological malignancies according to the presence of unilineage or multilineage cytopenias in the entire evaluable Lifelines cohort (n = 152 096).
| . | n* . | Unadjusted HR (95% CI) . | P . | Adjusted HR (95% CI)† . | P . |
|---|---|---|---|---|---|
| Anemia | 6156 | 4.71 (2.83-7.86) | <.001 | 4.55 (2.67-7.73) | <.001 |
| Thrombocytopenia | 2408 | 7.32 (3.91-13.70) | <.001 | 3.71 (1.90-7.27) | <.001 |
| Neutropenia | 6925 | 3.41 (1.90-6.14) | <.001 | 3.41 (1.87-6.20) | <.001 |
| >1 cytopenia | 861 | 18.20 (9.13-36.40) | <.001 | 14.37 (7.00-29.47) | <.001 |
| . | n* . | Unadjusted HR (95% CI) . | P . | Adjusted HR (95% CI)† . | P . |
|---|---|---|---|---|---|
| Anemia | 6156 | 4.71 (2.83-7.86) | <.001 | 4.55 (2.67-7.73) | <.001 |
| Thrombocytopenia | 2408 | 7.32 (3.91-13.70) | <.001 | 3.71 (1.90-7.27) | <.001 |
| Neutropenia | 6925 | 3.41 (1.90-6.14) | <.001 | 3.41 (1.87-6.20) | <.001 |
| >1 cytopenia | 861 | 18.20 (9.13-36.40) | <.001 | 14.37 (7.00-29.47) | <.001 |
Estimates were obtained by competing risk regression, according to the method of Fine and Gray, taking into account death from other causes as a competing risk. Individuals with an absence of the respective cytopenia or a multilineage cytopenia were used as the reference. Anemia: hemoglobin concentration <13.0 g/dL in men and <12.0 g/dL in women; thrombocytopenia: platelet count <150 × 109/L; neutropenia: neutrophil count <1.8 × 109/L.
Number of individuals with the respective cytopenia evaluable for cause of death.
The multivariable model included age and sex as covariates.