Relationship between ΔIKZF1 and MRD
| . | IKZF1 WT . | ΔIKZF1 . | IKZF1 plus . | P* . | ΔIKZF1 LOF . | ΔIKZF1 DN . | P, LOF vs WT/ DN vs WT . |
|---|---|---|---|---|---|---|---|
| PCR | Deleted vs WT | ||||||
| BCR-ABL1−† | |||||||
| MRD− | 147 (76.6) | 18 (51.4) | .002 | 8 (50.0) | 10 (52.6) | .019/.023 | |
| MRD+ | 45 (23.4) | 17 (48.6) | 8 (50.0) | 9 (47.4) | |||
| BCR-ABL1+ | |||||||
| MRD− | 42 (60.9) | 26 (55.3) | .55 | 10 (47.6) | 16 (61.5) | .28/.95 | |
| MRD+ | 27 (39.1) | 21 (44.7) | 11 (52.4) | 10 (38.5) | |||
| MLPA | Deleted vs WT/Deleted vs IKZF1plus | ||||||
| BCR-ABL1−† | |||||||
| MRD− | 112 (76.2) | 11 (52.4) | 22 (66.7) | .021/.26 | 25 (64.1) | 8 (57.1) | .12/.50 |
| MRD+ | 35 (23.8) | 10 (47.6) | 11 (33.3) | 14 (35.9) | 6 (42.9) | ||
| BCR-ABL1+ | |||||||
| MRD− | 27 (58.7) | 15 (44.1) | 22 (75.9) | .20/.13 | 24 (57.1) | 13 (65.0) | .31/.21 |
| MRD+ | 19 (41.3) | 19 (55.9) | 7 (24.1) | 18 (42.9) | 7 (35.0) |
| . | IKZF1 WT . | ΔIKZF1 . | IKZF1 plus . | P* . | ΔIKZF1 LOF . | ΔIKZF1 DN . | P, LOF vs WT/ DN vs WT . |
|---|---|---|---|---|---|---|---|
| PCR | Deleted vs WT | ||||||
| BCR-ABL1−† | |||||||
| MRD− | 147 (76.6) | 18 (51.4) | .002 | 8 (50.0) | 10 (52.6) | .019/.023 | |
| MRD+ | 45 (23.4) | 17 (48.6) | 8 (50.0) | 9 (47.4) | |||
| BCR-ABL1+ | |||||||
| MRD− | 42 (60.9) | 26 (55.3) | .55 | 10 (47.6) | 16 (61.5) | .28/.95 | |
| MRD+ | 27 (39.1) | 21 (44.7) | 11 (52.4) | 10 (38.5) | |||
| MLPA | Deleted vs WT/Deleted vs IKZF1plus | ||||||
| BCR-ABL1−† | |||||||
| MRD− | 112 (76.2) | 11 (52.4) | 22 (66.7) | .021/.26 | 25 (64.1) | 8 (57.1) | .12/.50 |
| MRD+ | 35 (23.8) | 10 (47.6) | 11 (33.3) | 14 (35.9) | 6 (42.9) | ||
| BCR-ABL1+ | |||||||
| MRD− | 27 (58.7) | 15 (44.1) | 22 (75.9) | .20/.13 | 24 (57.1) | 13 (65.0) | .31/.21 |
| MRD+ | 19 (41.3) | 19 (55.9) | 7 (24.1) | 18 (42.9) | 7 (35.0) |
P values are χ2. P values for interaction (with BCR-ABL1 status): P = .096 (PCR WT/ΔIKZF1), P = .39 (PCR, WT/LOF/DN), P = .0078 (MLPA WT/ΔIKZF1/IKZF1+), and P = .5 (MLPA, WT/LOF/DN).
For this analysis, negative was grouped together with indeterminate and POQR as this was how patients without a positive result were stratified to treatment.