Clinical response is correlated with matching at sites of predicted HLA restriction as determined by single peptide intracellular flow cytometry
| VST recipient . | VST source . | VST product received . | Predicted sites of HLA restriction based on single peptide flow cytometry . | Sites of HLA match between products and recipient . | Clinical response . |
|---|---|---|---|---|---|
| UPN-20 | Third-party | 2777-62 | A*01:01, DRB1*03:01, DRB1*07:01 | A*01:01, B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 | CR |
| UPN-32 | Third-party | 2777-62 | A*01:01, DRB1*03:01, DRB1*07:01 | A*01:01, B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 | PR |
| UPN-34 | Third-party | 2777-63 | DRB1*07:01 | A*02:05, B*50:01, C*06:02, DRB1*07:01, DQB1*02:02 | CR |
| UPN-59 | Third-party | 2777-113 | DRB1*03:01, DRB1*04:01 | A*02:01, DRB1*03:01, DQB1*02:01 | PR |
| UPN-69 | Third-party | 2777-167 | DRB1*03:01. DRB1*04:01 (minimal activity) | A*02:01, C*07:01, DRB1*04:01 | NR |
| UPN-105 | Donor-derived | 2777-105 | B*35:08, DRB1*03:01, DRB1*15:01 | A*03:01, A*31:01, B*35:08, B*50:01 C*04:01, C*06:02, DRB1*03:01, DQB1*06:02 | CR |
| VST recipient . | VST source . | VST product received . | Predicted sites of HLA restriction based on single peptide flow cytometry . | Sites of HLA match between products and recipient . | Clinical response . |
|---|---|---|---|---|---|
| UPN-20 | Third-party | 2777-62 | A*01:01, DRB1*03:01, DRB1*07:01 | A*01:01, B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 | CR |
| UPN-32 | Third-party | 2777-62 | A*01:01, DRB1*03:01, DRB1*07:01 | A*01:01, B*08:01, C*07:01, DRB1*03:01, DQB1*02:01 | PR |
| UPN-34 | Third-party | 2777-63 | DRB1*07:01 | A*02:05, B*50:01, C*06:02, DRB1*07:01, DQB1*02:02 | CR |
| UPN-59 | Third-party | 2777-113 | DRB1*03:01, DRB1*04:01 | A*02:01, DRB1*03:01, DQB1*02:01 | PR |
| UPN-69 | Third-party | 2777-167 | DRB1*03:01. DRB1*04:01 (minimal activity) | A*02:01, C*07:01, DRB1*04:01 | NR |
| UPN-105 | Donor-derived | 2777-105 | B*35:08, DRB1*03:01, DRB1*15:01 | A*03:01, A*31:01, B*35:08, B*50:01 C*04:01, C*06:02, DRB1*03:01, DQB1*06:02 | CR |
Numbers in bold represent alleles that are shared by VST donor and recipient and are predicted to be sites of HLA restriction.